dismiss

Need Spare Parts? Try the All-New Parts Hunter+EasyPay -- Learn more here

SEARCH
Current Location:
>
> This Story


Log in or Register to rate this News Story
Forward Printable StoryPrint Comment

Never Miss a Story

Sign up for email alerts

 

More Industry Headlines

No anxiety over false positive CT lung cancer results May influence CMS's coverage decision

FDA approves Philips' mobile ultrasound Product for the globe

ACR calls for tomo coverage CMS will decide in October

Dunlee to introduce new tube at RSNA Company confirms continued commitment to tube manufacturing

Radiotherapy steps outside of cancer treatment Shows promise for heart disease

Setting the Standard: XR-29 and the Importance of CT Dose Optimization Next step to reducing dose

Data collection system personalizes cancer treatment Predicts possible side effects

Hidden info in PET images aids cancer treatment Largest study of its kind

Survey shows U.S. hospital performance The health care system receives a mixed review

Standardizing breast density notification First bill that sets minimum federal standard

ASTRO 2012: Antidepressant 'rinse' could relieve RT mouth pain

by Brendon Nafziger , DOTmed News Associate Editor
Patients with head and neck cancers who receive radiation therapy often develop painful mouth and throat sores. But an antidepressant mouth rinse might help make the pain more bearable, according to a study presented Monday at ASTRO 2012 in Boston.

The double-blind, phase 3 randomized control trial found a mouthwash made of Doxepin, a tricyclic antidepressant, outperformed a placebo rinse in relieving pain from oral mucositis. Also, two-thirds of patients who tried the Doxeprin wash found it helpful enough to ask for a prescription for it.

Story Continues Below Advertisement

RISMED Oncology Systems - Linear Accelerator Systems, Parts & Service

RISMED Oncology Systems is one of the most experienced oncology equipment companies with services that can help you from the selection of a site to the daily management of your oncology center. Call 256.585.9881



"We think it can be used in addition to other (pain relief) agents at this point," study author Dr. Robert C. Miller, a radiation oncologist with Mayo Clinic in Rochester, Minn., told reporters during a press conference Monday. "It's not going to get rid of narcotics, but hopefully it will help people take less."

Doxepin goes by the brand names Adapin, Silenor and Sinequan.

The study, which took place in 26 institutions and involved 155 patients, followed patients for about four hours after receiving their first round of radiation and either a placebo or the Doxepin rinse. For their next fraction, the patients were crossed over to the other rinse.

According to Miller, patients just swishing around a placebo rinse, which was basically just water, experienced pain relief: pain went down an average of 1 point on a 10-point scale. With Doxepin, pain went down about 2 points on average, for a statistically significant difference, he said.

When asked whether they'd like to continue with the Doxepin rinse, 64 percent asked for a prescription, he said.

The Doxepin rinse had no serious side effects, but it did have some mild ones, such as a temporary burning sensation or unpleasant taste. Between 10 and 40 percent of people also experienced drowsiness after using it, and Miller said many patients preferred to take it at night, to help them sleep.

"Compared to placebo, we think Doxepin is an effective agent to reduce pain from oral mucositis," he said.

He also said the drug might be useful in other areas besides oral mucositis pain control - such as for people with nasty canker sores.

The study, "N09C6 (Alliance) - A Phase III, Randomized Double-Blind Study of Doxepin Rinse versus Placebo in the Treatment of Acute Oral Mucositis Pain in Patients Receiving Head and Neck Radiotherapy with or without Chemotherapy," was part of a series given at ASTRO on patient outcomes and perspectives on radiation treatment. It was conducted with the Alliance for Clinical Trials in Oncology.

Back to DOTmed News
  Pages: 1

Related:


Interested in Medical Industry News? Subscribe to DOTmed's weekly news email and always be informed. Click here, it takes just 30 seconds.

You Must Be Logged In To Post A Comment

Access and use of this site is subject to the terms and conditions of our LEGAL NOTICE & PRIVACY NOTICE
Property of and Proprietary to DOTmed.com, Inc. Copyright ©2001-2014 DOTmed.com, Inc.
ALL RIGHTS RESERVED