DOTmed Home MRI Oncology Ultrasound Molecular Imaging X-Ray Cardiology Health IT Business Affairs
News Home Parts & Service Operating Room CT Women's Health Proton Therapy Endoscopy HTMs Mobile Imaging
SEARCH
Current Location:
>
> This Story


Log in or Register to rate this News Story
Forward Printable StoryPrint Comment

 

More Industry Headlines

Cleveland Clinic, American Cancer Society dump Trump's Mar-A-Lago Mounting blowback from health care industry in wake of Virginia aftermath

INSIGHTEC's Exablate Neuro hits 1,000 patient mark System installed in 30 medical facilities worldwide

Medica to acquire Mayo Clinic Health Solutions May improve access for patients with complex conditions

Enterprise imaging will make up 27 percent of imaging IT market by 2021 PACS vendors ramp up enterprise solutions to compete against multi-vendor IT models

Robotic-assisted transhiatal esophagectomy is safe and effective for certain patients But it's a complex procedure to perform

Machine learning algorithm may predict early-stage Alzheimer's disease Already used for cancer

Stryker’s Serrato Pedicle Screw gets FDA nod Part of the Xia 3 Spinal System

Siemens Healthineers collaborates with Houston Methodist Hospital Will provide advanced angio, MR, CT, molecular imaging and ultrasound technology

Nationwide hosts IAMERS forum on QMS in advance of FDA report Stakeholders discuss ISO quality management systems

Insight Imaging acquires LG Medical Technologies Adds 27 mobile diagnostic imaging units to its fleet

ASTRO 2012: Antidepressant 'rinse' could relieve RT mouth pain

by Brendon Nafziger , DOTmed News Associate Editor
Patients with head and neck cancers who receive radiation therapy often develop painful mouth and throat sores. But an antidepressant mouth rinse might help make the pain more bearable, according to a study presented Monday at ASTRO 2012 in Boston.

The double-blind, phase 3 randomized control trial found a mouthwash made of Doxepin, a tricyclic antidepressant, outperformed a placebo rinse in relieving pain from oral mucositis. Also, two-thirds of patients who tried the Doxeprin wash found it helpful enough to ask for a prescription for it.

Story Continues Below Advertisement

Ventilators Plus -The Easy #1 Choice In Ventilator Sales, Rentals & Support

Our name says it all! Ventilators Plus is a full service depot repair facility offering on-site service as well. We BUY, SELL & RENT all models & also have a FULLY STOCKED parts warehouse available online 24/7. Call 888-889-2992.



"We think it can be used in addition to other (pain relief) agents at this point," study author Dr. Robert C. Miller, a radiation oncologist with Mayo Clinic in Rochester, Minn., told reporters during a press conference Monday. "It's not going to get rid of narcotics, but hopefully it will help people take less."

Doxepin goes by the brand names Adapin, Silenor and Sinequan.

The study, which took place in 26 institutions and involved 155 patients, followed patients for about four hours after receiving their first round of radiation and either a placebo or the Doxepin rinse. For their next fraction, the patients were crossed over to the other rinse.

According to Miller, patients just swishing around a placebo rinse, which was basically just water, experienced pain relief: pain went down an average of 1 point on a 10-point scale. With Doxepin, pain went down about 2 points on average, for a statistically significant difference, he said.

When asked whether they'd like to continue with the Doxepin rinse, 64 percent asked for a prescription, he said.

The Doxepin rinse had no serious side effects, but it did have some mild ones, such as a temporary burning sensation or unpleasant taste. Between 10 and 40 percent of people also experienced drowsiness after using it, and Miller said many patients preferred to take it at night, to help them sleep.

"Compared to placebo, we think Doxepin is an effective agent to reduce pain from oral mucositis," he said.

He also said the drug might be useful in other areas besides oral mucositis pain control - such as for people with nasty canker sores.

The study, "N09C6 (Alliance) - A Phase III, Randomized Double-Blind Study of Doxepin Rinse versus Placebo in the Treatment of Acute Oral Mucositis Pain in Patients Receiving Head and Neck Radiotherapy with or without Chemotherapy," was part of a series given at ASTRO on patient outcomes and perspectives on radiation treatment. It was conducted with the Alliance for Clinical Trials in Oncology.

Back to HCB News
  Pages: 1

Related:


You Must Be Logged In To Post A Comment

Advertise
Increase Your
Brand Awareness
Auctions + Private Sales
Get The
Best Price
Buy Equipment/Parts
Find The
Lowest Price
Daily News
Read The
Latest News
Directory
Browse All
DOTmed Users
Ethics on DOTmed
View Our
Ethics Program
Gold Parts Vendor Program
Receive PH
Requests
Gold Service Dealer Program
Receive RFP/PS
Requests
Healthcare Providers
See all
HCP Tools
Jobs/Training
Find/Fill
A Job
Parts Hunter +EasyPay
Get Parts
Quotes
Recently Certified
View Recently
Certified Users
Recently Rated
View Recently
Certified Users
Rental Central
Rent Equipment
For Less
Sell Equipment/Parts
Get The
Most Money
Service Technicians Forum
Find Help
And Advice
Simple RFP
Get Equipment
Quotes
Virtual Trade Show
Find Service
For Equipment
Access and use of this site is subject to the terms and conditions of our LEGAL NOTICE & PRIVACY NOTICE
Property of and Proprietary to DOTmed.com, Inc. Copyright ©2001-2017 DOTmed.com, Inc.
ALL RIGHTS RESERVED