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New study finds interventional weight-loss procedure safe for morbidly obese patients

Press releases may be edited for formatting or style | February 14, 2017 X-Ray
OAK BROOK, Ill. — A novel interventional radiology technique for weight loss is safe and well tolerated in morbidly obese individuals, according to a new study appearing in the online edition of Radiology. Though the results are preliminary, the technique has the potential to be a new weapon in the war on obesity.

Obesity—defined as a body mass index (BMI), or measure of body fat based on weight and height, of 30 or more—is a major public health problem that affects more than one-third of Americans, according to the National Institute of Diabetes and Digestive and Kidney Diseases. Obese people face an increased risk of diabetes, stroke, heart attack and other major health issues. Traditional approaches like a low-calorie diet, behavior modification, exercise and medication have shown limited effectiveness. One of the more successful interventions has been bariatric surgery, but its invasiveness can result in significant complications.

Trans-arterial embolization of the gastric fundus, also known as bariatric embolization, has emerged in recent years as another potential weight-loss tool. The technique itself has been used for decades to stop bleeding in the gastric artery, but the idea of using it to treat obesity arose more recently based on observations of hormonal changes in patients who underwent bariatric surgery.
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“A number of research papers in the 1990s found signs of hormonal changes after bariatric surgery,” said the study’s lead author, Clifford R. Weiss, M.D., from the Johns Hopkins University School of Medicine in Baltimore. “In particular, there was a pretty rapid reduction in ghrelin, the most potent hunger-stimulating hormone we know. The hormone is produced in an area of the stomach called the fundus, which is fed primarily by the left gastric artery.”

In bariatric embolization, very small, bead-like particles are introduced into the left gastric artery, using imaging guidance and minimally invasive techniques. Once in place, they obstruct the circulation of blood, leading to ischemia and a reduction in ghrelin production. Researchers at the Johns Hopkins University School of Medicine have developed and studied the technique for weight loss over the last 10 to 12 years, Dr. Weiss said.

This phase of the study (June 2014 to August 2015) included results from the first five patients, four of whom were women. Prior to intervention, the patients were morbidly obese, with a mean BMI of 43.8. Using fluoroscopic guidance, interventional radiologists were able to embolize the left gastric artery in all five patients with 300- to 500-micrometer beads. The patients experienced an average weight loss of 5.9 percent at one month and 9.0 percent at three months. Serum ghrelin levels dropped 17.5 percent, on average, at three months. There was a trend toward improvement in quality-of-life parameters. There were no major adverse events in the study group.

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