Optimizing speed
To speed up the imaging process, the researchers made their Raman system more compatible with the algorithm. They did this by replacing the expensive and slow cameras used in conventional setups with a cheap and fast digital micromirror device known as a spatial light modulator. This device selects groups of wavelengths that are detected by a highly sensitive single-pixel detector, compressing the images as they are acquired.
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“A very fast spatial light modulator made it possible to acquire images and skip data bits very quickly,” said de Aguiar. “The spatial light modulator we used is orders of magnitude less expensive and faster than other options on the market, making the overall optical setup cheap and fast.”
The researchers demonstrated their new methodology using a Raman microscope to obtain spectroscopy images from brain tissue and single cells, both of which exhibit high chemical complexity. Their results showed that the method can acquire images at speeds of a few tens of seconds and accomplish a high level of data compression — reducing the data up to 64 times.
The researchers believe that the new approach should work with most biological specimens, but they plan to test it with more tissue types to demonstrate this experimentally. In addition to clinical tools, the method could be useful for biological applications such as algae characterization. They also want to improve the scanning speed of their system to accomplish sub-second image acquisition.
Paper: F. Soldevila, J. Dong, E. Tajahuerce, S. Gigan, H. B. De Aguiar, “Fast compressive Raman bio-imaging via matrix completion,” Optica, 6, 3, 341-346 (2019).
DOI: https://doi.org/10.1364/OPTICA.6.000341
About Optica
Optica is an open-access, online-only journal dedicated to the rapid dissemination of high-impact peer-reviewed research across the entire spectrum of optics and photonics. Published monthly by The Optical Society (OSA), Optica provides a forum for pioneering research to be swiftly accessed by the international community, whether that research is theoretical or experimental, fundamental or applied. Optica maintains a distinguished editorial board of more than 60 associate editors from around the world and is overseen by Editor-in-Chief Alex Gaeta, Columbia University, USA.
About The Optical Society
Founded in 1916, The Optical Society (OSA) is the leading professional organization for scientists, engineers, students and business leaders who fuel discoveries, shape real-life applications and accelerate achievements in the science of light. Through world-renowned publications, meetings and membership initiatives, OSA provides quality research, inspired interactions and dedicated resources for its extensive global network of optics and photonics experts.
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