Scientists at Johns Hopkins have successfully created personalized digital replicas of the upper chambers of the heart and used them to guide the precise treatment of patients suffering from persistent irregular heartbeats. These simulations accurately identified where clinicians need to destroy tissue to restore the heart's normal rhythm.
The proof-of-concept study, published today in Nature Biomedical Engineering, is a promising step toward simulation-driven treatments and sets the stage for the team's FDA-approved clinical trial slated to begin this fall.
"The personalized digital replicas allowed us to accurately simulate and analyze heart electrical activity in 10 patients and determine where tissue needs to be destroyed," says Natalia Trayanova, the study's corresponding author and a professor in the Department of Biomedical Engineering, which is shared by the schools of Engineering and Medicine.
"The beauty of working with such replicas is that we could test for and predict where irregular heartbeats persist in ways we never could in the clinic," says Trayanova. "We ran a mock of the clinical procedure over and over again, until we were sure irregular beats will not re-emerge."
She says the approach has the potential to eliminate the process of trial-and-error in treating such heart rhythm disorders and to prevent repeat procedures.
Abnormal electrical signals stemming from the heart's two upper chambers, the atria, is the most common cause of irregular heartbeats and affects 1-2% of people worldwide. If left untreated, the condition, called atrial fibrillation, can cause fatal strokes.
The typical treatment for the disorder involves threading a catheter that emits radio frequency into the heart to destroy tissue that sends off erratic electrical signals. Specifically, cardiologists will destroy tissue around the atria's four pulmonary veins where researchers believe the misfiring signals usually begin.
However, a subset of patients with a persistent form of atrial fibrillation and scarring in the atria don't benefit from receiving standard lesions around the pulmonary veins and often have to undergo multiple procedures because abnormal signals continue to emerge in new areas of their atria. With each procedure, new scar tissue forms, which changes the atria's electrical activity and makes targeting of the misfiring areas that much harder.
The team's personalized simulation-driven guidance of the ablation procedure, called Optimal Target Identification via Modelling of Arrhythmogenesis, or OPTIMA, used contrast-enhanced MRI scans from 10 patients at the Johns Hopkins Hospital to create personalized digital replicas of the diseased atria.
