October, 30--As a frequently used replacement to study human diseases, mouse models play a vital role in the development of scientific research. Scientists from Creative Animodel, Inc. labs found mouse models great potential and attached much attention to it. Today, we can get more clues of Knock-in Mouse Model from them.

Creative Animodel provides a high quality service for the generation of gene-targeted knock-in mouse models. Its team has many years of experience in vector design, ES cell targeting and mouse handling. Scientists from Creative Animodel totally know that it is their duty to contribute to human disease research. They introduce different types of Knock-in designs as below.
First but not least, Knock-in mouse model includes custom humanized mouse Services. This type of mouse models are extensively used as the replacement of in vivo study of human diseases, such as AIDS, cancer, infectious diseases, immune diseases, degenerative diseases, etc. Creative Animodel will deliver its services with the highest possible quality standards, and will make sure the selected customers will be satisfied with the entire process of paid activities

Second, it is Point mutant. It introduces a specific point mutation at a specific nucleotide position within the gene of interest. The mutated mouse gene substitutes for the wild type mouse gene while ostensibly preserving the endogenous regulatory regions.

Third, inducible point mutant - Introduces a point mutation in a time-controlled manner. This strategy allows the scientists to bypass the limits usually observed with constitutive point mutant such as lethal phenotype, compensatory mechanisms and complex phenotype.

Fourth, knock-in services design also contains reporter and tag. This introduces a reporter gene such as GFP, lacZ, mCherry, tdTomato, YFP and DsRed into the locus of a target gene in order to monitor the expression of that gene at the transcriptional or translational level. May also be used to monitor protein trafficking.

At last, we can also have permissive locus (HPRT/Rosa26). It introduces a safe and targeted insertion of a transgene into the HPRT locus and Rosa26 locus.

A senior scientist from Creative Animodel told us Knock-in mouse model services can be divided in two categories, namely in vivo Model and in vitro Model. And the details about how it works? "[We] have the construction of target vector, establishment of ES close, and production of chimeric mouse. Then you can also get confirmation of germ line transmission. That's full-services knockin mouse production. In one word, a fully customized mouse model tailored to your research program will achieve your goals."

Nowadays, scientists are confronted with more and more complicated diseases, such as Ebola. They must use more efficient way to get over them to save human beings. Mouse model comes to the stage depending on its all kinds of benefits. Creative Animodel will continue to make a good use of this technology, and contribute to more people.

For more details, you can visit http://www.creative-animodel.com or directly email at info@Creative-Animodel.com for further information.

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