Patient B, a 39-year old female was found to have a locally advanced high-grade rectal NET. She was treated with chemotherapy and radiation but developed progressive disease with metastases, and worsening rectal pain. After her genomic profiling revealed BRAFV600E substitution at an (MAF) of 53 percent, she was transitioned to two other drugs, and within three days her pain issue was resolved, followed by dramatic radiographic response.
"Finding driver mutations, which are the engines of the cancer cell, in uncommon cancers can sometimes provide a unique treatment option for those patients," Gershenhorn said. "This case is a great example of the benefits of NGS in patients with rare tumors, by finding a common and 'targetable' driver, extrapolating from what is known about the mutation in another cancer type, and using a powerful, precision drug combination to target that engine."
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You can obtain additional information about this study by using the following link. For additional information about neuroendocrine cancers and treatment options, please visit cancercenter.com.
About Cancer Treatment Centers of America®
Cancer Treatment Centers of America Global, Inc. (CTCA), headquartered in Boca Raton, Fla., is a national network of five hospitals that serves adult patients who are fighting cancer. CTCA® offers an integrative approach to care that combines advancements in genomic testing and precision cancer treatment, surgery, radiation, immunotherapy and chemotherapy, with evidence-based supportive therapies designed to help patients physically and emotionally by enhancing their quality of life while managing side effects both during and after treatment. CTCA serves patients from around the world at its hospitals in Atlanta, Chicago, Philadelphia, Phoenix and Tulsa. Consistently rated among U.S. hospitals that deliver the highest quality of care and patient experience, CTCA provides patients and their families with comprehensive information about their treatment options and encourages their active participation in treatment decisions. For more information, visit cancercenter.com, Facebook.com/cancercenter and Twitter.com/cancercenter.
About Cancer Treatment Centers of America® at Midwestern Regional Medical Center
Cancer Treatment Centers of America® (CTCA) at Midwestern Regional Medical Center (Midwestern) is a landmark in cancer care that uses advanced technology and precision medicine to offer treatment for adult patients battling cancer. The 72-bed hospital combines innovative conventional medical treatments with evidence-based integrative oncology services to deliver whole-person care. CTCA® at Midwestern is a Magnet Recognized® hospital, ranking among the top centers in the nation for nursing excellence. The hospital is accredited by the Foundation for the Accreditation of Cellular Therapy (FACT) at the University of Nebraska Medical Center for demonstrating compliance with the FACT-JACIE International Standards for Cellular Therapy Product Collection, Processing and Administration. CTCA at Midwestern also holds high honors as a Certified Quality Breast Center of Excellence™, recognized by the National Quality Measures for Breast Centers Program™ (NQMBC®). For more information, please visit www.cancercenter.com/midwestern.
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