"Reducing treatment volumes and sparing healthy tissue is a critical factor in improving the care and outcomes for patients treated with radiation therapy," said Arjun Sahgal, MD, Deputy Chief of the Department of Radiation Oncology at Sunnybrook. "These preliminary data suggest that the integrated, high-field MR imaging capabilities of MR-linac could enable online plan adaptation in response to changes in tumor volume and surrounding structures during treatment. These adaptations could enable reduced treatment volumes and protection of critical organs and structures."
The potential of MR/RT to provide greater insights into the biology of cancer was also featured at the conference. Allen Li, PhD, Professor and Chief of Medical Physics at Froedtert & Medical College of Wisconsin moderated and participated in a panel discussion titled "MRI-guided adaptation: From anatomy to biology" (Panel 04). The discussion focused on recent advances in using MRI to assess treatment response and guide adaptive radiation therapy practices, including: a review of data that provide insight into using advanced MRI technologies to assess or monitor radiation therapy responses in selected tumor sites; algorithms and tools required for treatment plan adaptation based on treatment responses; and opportunities and challenges related to the use of advanced MRI in clinical practice.
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Additional abstracts related to the development of MR-linac presented at the conference include:
Quantifying complex abdominal organ motions in different time frames in radiation therapy (Abstract #3669)
This abstract reports results of a study that investigated abdominal motion induced by respiration and peristalsis during various time durations relevant to radiation therapy. The study used a variety of CT and MRI techniques to acquire images of tumors and surrounding tissue in 31 patients with pancreatic or liver cancer. Images were captured while patients engaged in free breathing (FB) and breath hold (BH). Investigators conclude that the abdominal motions due to peristalsis in the time frames from seconds to minutes can be similar in magnitude to motion resulting from breathing. These motions can be irregular and persistent throughout the imaging and radiation therapy delivery procedures, and should be considered together with respiration motion during radiation therapy for abdominal tumors.
