In addition to serving as a roadmap for future research studies of Alzheimer’s disease, the new results also have a clinical benefit:
“Now that we know where Alzheimer’s disease begins, we can improve the diagnostics by focusing more clearly on these parts of the brain, for example in medical imaging examinations with a PET camera”, says Oskar Hansson, professor at Lund University, and medical consultant at Skåne University Hospital.
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Although the first symptoms of Alzheimer’s become noticeable to others much later, the current study shows that the brain’s communication activity changes in connection with the early retention of β-amyloid. How, and with what consequences, will be examined by the research team in further studies.
The current study was funded by the European Research Council (ERC), the Swedish Research Council (VR), the Swedish Alzheimer’s Foundation and Region of Skåne (through ALF funding).
Publication: Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity
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