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Cedars-Sinai and Emulate, Inc. advance precision medicine with organs-on-chips and stem cells

Press releases may be edited for formatting or style | February 20, 2018 3D Printing

Emulate’s Human Emulation System — which is made up of Organs-on-Chips, instrumentation and software apps — re-creates the natural physiology cells experience within the body. Each chip, which is approximately the size of an AA battery, features tiny channels lined with tens of thousands of living human cells, recreating the smallest functional unit of an organ. Air and fluid, such as blood, can be passed through the chips, creating a micro-engineered environment that is a "home-away-from-home" for cells, where they behave just as they do in the body.

"By creating a personalized Patient-on-a-Chip, we can really begin to understand how diseases, medicines, chemicals and foods affect an individual’s health," said Geraldine A. Hamilton, PhD, president and chief scientific officer of Emulate, Inc. "The goal of Emulate working with Cedars-Sinai is to advance and qualify the system for new clinical applications and ultimately democratize the technology so that it can have broad impact on patient healthcare."

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In the future, a Patient-on-a-Chip also could be used to predict how a disease progresses in an individual, allowing for the design of personalized preventive medicine and treatment regimens to promote wellness and prevent disease, said Robert Barrett, PhD, an assistant professor of Medicine at Cedars-Sinai and senior author of the study in Cellular and Molecular Gastroenterology and Hepatology. Other applications include designing clinical trials to identify at-risk populations for adverse drug reactions.

"Cedars-Sinai's world-class stem cell expertise and discovery, combined with Emulate's pioneering Human Emulation System, is poised to reshape the future of medical care," said Shlomo Melmed, MB, ChB, executive vice president, Academic Affairs, and dean of the medical faculty at Cedars-Sinai. "This project is an important initiative of Cedars-Sinai Precision Health, whose goal is to drive the development of the newest technology and best research, coupled with the finest clinical practice, to rapidly enable a new era of personalized health."

About Cedars-Sinai
Cedars-Sinai is a national leader in providing high-quality, patient-centered healthcare encompassing primary care as well as specialized medicine and conducting research that leads to lifesaving discoveries and innovations. Since its beginning in 1902, Cedars-Sinai has evolved to meet the healthcare needs of one of the most diverse regions in the nation, continually setting new standards in quality and innovation in patient care, research, teaching and community service. Today, Cedars-Sinai is widely known for its national leadership in transforming healthcare for the benefit of patients. Cedars-Sinai impacts the future of healthcare globally by developing new approaches to treatment and educating tomorrow’s physicians and other health professionals. At the same time, Cedars-Sinai demonstrates a longstanding commitment to strengthening the Los Angeles community through wide-ranging programs that improve the health of its most vulnerable residents.

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