The vast majority of patients in both groups–upwards of 85 percent–received appropriate guideline-directed treatment for post-heart attack management, as well as heart failure management given patients' reduced ejection fraction. At the end of the study, researchers searched the National Death Index for participants lost to follow up. The rate of cardiovascular-related re-hospitalizations was 25 percent and was similar in both groups.
The study was originally designed with a primary outcome of total mortality. However, because of enrollment difficulties early in the study, the estimated sample size of 4,500 participants became infeasible. After the first 213 participants were enrolled in 2010, the primary outcome was changed to sudden death with a pre-specified secondary outcome of total mortality, Olgin said.
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He and his team are working on a number of additional analyses from this study. They also plan on transitioning patients into a registry for longer-term follow up.
This study was funded, in part, by the National Institutes of Health and Zoll Medical Corporation, which makes the LifeVest WCD.
The ACC's Annual Scientific Session, which is taking place March 10-12 in Orlando, brings together cardiologists and cardiovascular specialists from around the world to share the newest discoveries in treatment and prevention. Follow @ACCinTouch, @ACCMediaCenter and #ACC18 for the latest news from the meeting.
The American College of Cardiology is a 52,000-member medical society that is the professional home for the entire cardiovascular care team. The mission of the College is to transform cardiovascular care and to improve heart health. The ACC leads in the formation of health policy, standards and guidelines. The College operates national registries to measure and improve care, offers cardiovascular accreditation to hospitals and institutions, provides professional medical education, disseminates cardiovascular research and bestows credentials upon cardiovascular specialists who meet stringent qualifications.
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