"MR spectroscopy is quick, noninvasive and can be performed on any clinical MR scanner, making results available before any biopsy or surgical procedure have begun," says Andronesi, and assistant professor of Radiology at Harvard Medical School. "It also can be used to track the response to treatment, since repeat biopsies are not feasible for patients with brain tumors, by directly probing the activity of the mutant IDH1 enzyme. Of course, our small study needs to be replicated in a larger group with longer follow-up times, as well as determining the long-term benefit of IDH1 inhibitor treatment."
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The senior author of the Nature Communications paper is Tracy Batchelor, MD, Pappas Center for Neuro-Oncology in the MGH Cancer Center. Additional co-authors are Isabel C. Arrillaga-Romany, MD, K. Ina Ly, MBBS, Jorg Dietrich, MD, PhD, and Elizabeth Gerstner, MD, Pappas Center for Neuro-Oncology; Eva-Maria Ratai, PhD, and Bruce R. Rosen, MD, PhD, Martinos Center for Biomedical Imaging; Kara Reitz and Daniel Cahill, MD, PhD, MGH Neurosurgery; John Iafrate, MD, PhD, MGH Pathology; Wolfgang Bogner, PhD, Medical University of Vienna; Andrew Chi, MD, PhD, New York University Langone Medical Center; and Patrick Wen, MD, Dana-Farber Cancer Institute.
The study was funded by National Cancer Institute grants K22 CA178269, R01 CA211080, SPORE P50 CA165962, R01 CA129371 and K24 CA125440A; and National Institutes of Health grants S10 RR013026, S10 RR021110 and S10 RR023401.
Massachusetts General Hospital, founded in 1811, is the original and largest teaching hospital of Harvard Medical School. The MGH Research Institute conducts the largest hospital-based research program in the nation, with an annual research budget of more than $900 million and major research centers in HIV/AIDS, cardiovascular research, cancer, computational and integrative biology, cutaneous biology, genomic medicine, medical imaging, neurodegenerative disorders, regenerative medicine, reproductive biology, systems biology, photomedicine and transplantation biology. The MGH topped the 2015 Nature Index list of health care organizations publishing in leading scientific journals and earned the prestigious 2015 Foster G. McGaw Prize for Excellence in Community Service. In August 2017 the MGH was once again named to the Honor Roll in the U.S. News & World Report list of "America's Best Hospitals."
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