Despite FAST and similar trials supporting the use of accelerated radiation treatment for breast cancer, large numbers of eligible patients in the U.S. are not receiving, and likely not being offered, shorter courses of radiation therapy. A 2013 JAMA study found an adoption rate of approximately 30 percent in the U.S., and a 2017 analysis for Kaiser Health News indicated that fewer than half of patients over age 50 with early-stage disease receive the accelerated treatment. The current ASTRO clinical guideline for whole breast radiation therapy, which was issued earlier this year, recommends hypofractionated therapy for breast cancer patients regardless of age, tumor stage and whether they have received chemotherapy.
The abstract, "FAST phase III RCT of radiation therapy hypofractionation for treatment of early breast cancer: 10-Year results (CRUKE/04/015)," was presented in detail during a news briefing and the clinical trials session at ASTRO's 60th Annual Meeting in San Antonio.
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