PSMA is a cancer target (cell surface antigen) that is highly upregulated in prostate cancer cells and is a highly validated and promising target for a range of diagnostic and therapeutic strategies in prostate cancer.
About iPSMA (99mTc-EDDA/HYNIC-iPSMA)
99mTc-EDDA/HYNIC-iPSMA (99Tc-iPSMA) is a small molecule (ligand) that targets and binds to PSMA and enables metastatic prostate cancer can be imaged using Single-Photon Emission Computed Tomography (SPECT). SPECT is a highly effective and widely used imaging modality in the management of cancer. 99Tc-iPSMA is a development stage radiopharmaceutical imaging agent that is designed to facilitate the visualization of subtle changes in biochemical and biological processes associated with disease progression. The expression of distinct proteins by diseased cells offers the opportunity to "visualize cancer", potentially allowing for improved detection and staging, more precise biopsies, and a targeted treatment plan including active surveillance as a disease management tool.
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