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MR reveals brain damage in obese teens

Press releases may be edited for formatting or style | November 25, 2019 MRI

Worsening condition of the white matter was also associated with levels of insulin, a hormone produced in the pancreas that helps regulate blood sugar levels. Obese people often suffer from insulin resistance, a state in which the body is resistant to the effects of the hormone.

"Our maps showed a positive correlation between brain changes and hormones such as leptin and insulin," Dr. Bertolazzi said. "Furthermore, we found a positive association with inflammatory markers, which leads us to believe in a process of neuroinflammation besides insulin and leptin resistance."

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Dr. Bertolazzi noted that additional studies are needed to determine if this inflammation in young people with obesity is a consequence of the structural changes in the brain.

"In the future, we would like to repeat brain MRI in these adolescents after multi-professional treatment for weight loss to assess if the brain changes are reversible or not," she added.

Co-authors are Ricardo Uchida, D.Sc., Fabio L. Duran, D.Sc., Thaysa Neves, M.Sc., Elie Calfat, M.Sc., Naomi Costa, Estefania S. Fernandez, JoAnna D. Lima, Daniel A. Vasques, M.Sc., Cristiane Kochi, D.Sc., Marília Seelaender, D.Sc., Victor H. Otani, D.Sc., and Thais Z. Otani, D.Sc.

Note: Copies of RSNA 2019 news releases and electronic images will be available online at RSNA.org/press19 beginning Monday, Nov. 25.

RSNA is an association of over 53,400 radiologists, radiation oncologists, medical physicists and related scientists, promoting excellence in patient care and health care delivery through education, research and technologic innovation. The Society is based in Oak Brook, Ill. (RSNA.org)

Editor's note: The data in these releases may differ from those in the published abstract and those actually presented at the meeting, as researchers continue to update their data right up until the meeting.

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