"Our study shows that BU99008 can detect important reactive astrocytes with good selectivity and specificity, making it a potentially important clinical astrocytic PET tracer," says the paper's first author Amit Kumar, researcher at the Department of Neurobiology, Care Sciences and Society, Karolinska Institutet. "The results can improve our knowledge of the role played by reactive astrogliosis in Alzheimer's disease."
"As far as we can judge, this is the first time that BU99008 could visualises reactive astrogliosis in Alzheimer's disease brain," says principal investigator Agneta Nordberg, professor at the same department. "The results can have broad clinical implications that cover other disorders of reactive astroglial dysfunction."
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The study was financed with grants from the Swedish Foundation for Strategic Research (SSF), the Swedish Research Council (VR), the Region Stockholm-Karolinska Institutet ALF scheme for clinical research and medical education, the Swedish Brain Fund, the Swedish Alzheimer's Foundation, the Foundation for Old Servants, the Gun and Bertil Stohne Foundation, the Gunvor and Josef Aner Foundation, the Loo and Hans Osterman Medical Research Foundation, the Tore Nilson Foundation, the Swedish Dementia Association and the Centre for Innovative Medicine (CIMED) Stockholm Region. There are no reported conflicts of interest.
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