The data will be presented in more detail on Friday in two presentations at the peer-reviewed scientific conference1,2. Derived from AC Immune’s Morphomer® technology platform, ACI-12589 showed target engagement in vivo in alpha-synucleinopathies with a pharmacokinetic and safety profile suitable for further development as a human brain PET imaging agent. The trial showed that non-invasive PET brain imaging with ACI-12589 successfully differentiated MSA from other types of a-synucleinopathies, like Parkinson’s disease (PD) and Lewy Body Dementia (LBD), as well as from healthy volunteers.
Specifically, the ACI-12589 PET tracer data showed enhanced contrast and a-syn target specificity in participants with MSA. Tracer retention was highest in areas affected by MSA disease processes, particularly cerebellar white matter.
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a-syn Key Opinion Leader webinar on March 29th
In addition to the scientific presentations during AD/PDTM, AC Immune has organized a KOL webinar on March 29th at 10:00am ET / 4:00pm CET, where Dr. Hansson and AC Immune’s management will discuss ACI-12589 findings as well as the importance of biomarkers and precision medicine in neurodegenerative diseases. Additionally, members of the AC Immune management team will provide an overview of the Company’s clinical stage a-syn targeted therapeutic and diagnostic candidates.
About Multiple System Atrophy (MSA)
MSA is a rare, degenerative neurological disorder affecting the body’s involuntary (autonomic) functions, including blood pressure, breathing, bladder function and motor control. MSA causes deterioration and shrinkage (atrophy) of portions of the brain (cerebellum, basal ganglia and brainstem) that regulate internal body functions, digestion and motor control. Under a microscope, the damaged brain tissue of people with MSA shows nerve cells (neurons) that contain an abnormally high amount of pathological a-syn protein. MSA is difficult to diagnose and is often confused with PD (about 1 in 40 PD patients has MSA), and, currently, many MSA patients never receive a proper diagnosis. While there is overlap, therapeutic treatment strategies are different in MSA and PD; so, achieving a correct diagnosis is very important.
About AC Immune SA
AC Immune SA is clinical-stage biopharmaceutical company that aims to become a global leader in precision medicine for neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and NeuroOrphan indications driven by misfolded proteins. The Company’s two clinically validated technology platforms, SupraAntigen® and Morphomer®, fuel its broad and diversified pipeline of first- and best-in-class assets, which currently features ten therapeutic and three diagnostic candidates, six of which are currently in clinical trials. AC Immune has a strong track record of securing strategic partnerships with leading global pharmaceutical companies including Genentech, a member of the Roche Group, Eli Lilly and Company, and Janssen Pharmaceuticals, Inc., resulting in substantial non-dilutive funding to advance its proprietary programs and >$3 billion in potential milestone payments.
SupraAntigen® is a registered trademark of AC Immune SA in the following territories: AU, EU, CH, GB, JP and RU. Morphomer® is a registered trademark of AC Immune SA in CN, CH, GB, JP, and NO.
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