"The results suggest that BPE at postoperative surveillance breast MRI may indicate the response to breast cancer treatment and may be a predictor of the modified risk of second breast cancer after treatment in women with a personal history of breast cancer," Dr. Lee said.
The study findings point to a role for BPE measurements in refining screening pathways for women with prior breast cancer, Dr. Lee said.
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"Our study results may help to stratify the risk of second breast cancer in women with a personal history of breast cancer and to establish personalized imaging surveillance strategies in terms of imaging modality and monitoring interval selection," she said. "For example, women with minimal BPE at surveillance breast MRI may no longer need to undergo contrast-enhanced breast MRI every year if other risk factors are absent."
Those other risk factors include younger age at diagnosis, the presence of genetic mutations linked to breast cancer and hormone receptor expression in the initial breast cancer.
Areas for future study include the link between BPE changes at screening or preoperative breast MRI and at postoperative surveillance breast MRI and the development of second breast cancer.
In the future, Dr. Lee expects that risk models will use mammography, ultrasound and MRI together. This approach, she said, will lead to more tailored surveillance strategies for women with a history of breast cancer.
"Background Parenchymal Enhancement at Postoperative Surveillance Breast MRI: Association with Future Second Breast Cancer Risk." Collaborating with Dr. Lee were Myoung-jin Jang, Ph.D., Heera Yoen, M.D., Youkyoung Lee, M.D., Yeon Soo Kim, M.D., Ah Reum Park, M.D., Su Min Ha, M.D., Ph.D., Soo-Yeon Kim, M.D., Ph.D., Jung Min Chang, M.D., Ph.D., Nariya Cho, M.D., Ph.D., and Woo Kyung Moon, M.D., Ph.D.
Radiology is edited by David A. Bluemke, M.D., Ph.D., University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, and owned and published by the Radiological Society of North America, Inc. (https://pubs.rsna.org/journal/radiology)
RSNA is an association of radiologists, radiation oncologists, medical physicists and related scientists promoting excellence in patient care and health care delivery through education, research and technologic innovation. The Society is based in Oak Brook, Illinois.
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