Wayne, NJ, November 22, 2022 – Konica Minolta Healthcare Americas, Inc., a leader in medical diagnostic imaging and healthcare information technology, is pleased to announce the publication of a study that found Dynamic Digital Radiography (DDR) of the chest (aka DCR) delivers similar efficacy as lung ventilation perfusion (V/Q) for the detection of chronic thromboembolic pulmonary hypertension (CTEPH). In addition, DDR was performed without the need for contrast media and at a significantly lower radiation dose to the patient, approximately one-tenth of lung V/Q scintigraphy. The study by lead author Yuzo Yamasaki, MD, PhD, from Kyushu University (Fukuoka, Japan), was published November 8 in Radiology, the scientific journal of the Radiological Society of North America.

Dynamic Digital Radiography is a radiographic technique that provides a series of individual digital X-ray images acquired at high speed and low radiation dose. These images provide a diagnostic-quality view of anatomical structures in motion and the ability to visualize the dynamic interaction with physiological changes over time. DDR provides enriched radiographic information and enhanced diagnostic capabilities such as the ability to visualize pulmonary hemodynamics without contrast media, which is the subject of this research. CTEPH is a complication of pulmonary embolism and a significant cause of pulmonary hypertension with associated morbidity and mortality if left untreated. As a potentially treatable cause of pulmonary hypertension, identification of CTEPH with imaging may significantly impact clinical outcomes of patients with this condition.

The authors note that while early diagnosis of CTEPH is important for better patient outcomes, V/Q scanning is underused and there is a clinical need for an easy, noninvasive screening method. Compared to other modalities, including dual-energy CT and MRI, the authors wrote that DDR has several advantages, including low radiation dose and no contrast media or radionuclides. Additionally, both dual-energy CT and MRI are more technically challenging, more expensive, have limited availability, and lack multicenter validation. The authors conclude that DDR “may be a low-cost alternative to V/Q scanning for the diagnosis of this disease,” and they further note that the DDR system can also be used as a conventional X-ray system and installed in a smaller space than what is needed for a SPECT/CT system.
In an accompanying editorial, John C. Wandtke, MD, professor, and Katherine Kaproth-Joslin, MD, PhD, Department of Imaging Sciences, University of Rochester Medical Center, comment that a major advantage is that the radiation dose is approximately one-tenth that of lung V/Q scintigraphy, one-twentieth that of standard CT pulmonary angiography, and one-fifth that of low-dose CT pulmonary angiography. The authors further highlight the clinical value of DDR for CTEPH. They wrote that DDR may be a reliable alternative to contrast- and radionuclide-enhanced imaging methods and it “appears to represent an innovative method for fast and cost-effective screening of patients for CTEPH.”

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