Based on a patient's clinical-pathologic risk factors, radiation therapy is recommended to reduce the risk of locoregional recurrence. The choice of EBRT versus VBT in FIGO stage I endometrial cancer should depend on lymph node assessment and uterine risk factors. EBRT is recommended for patients with stage I disease with high-risk features, stage II disease or stage III-IVA disease.
Systemic chemotherapy should be effectively sequenced with radiation therapy for patients with high-risk histologies and/or stage III-IVA disease to decrease the risk of distant and locoregional recurrence, respectively.
When EBRT is indicated, the use of intensity-modulated radiation therapy with daily image-guidance is associated with improved patient-reported outcomes and reduced side effects. Recommendations in the guideline also outline optimal radiation dosing, treatment planning and delivery techniques based on the patient's cancer stage and histology.
For surgical nodal staging, sentinel lymph node mapping is recommended over pelvic lymphadenectomy, and the use of adjuvant therapy should be based on a patient's pathologic ultrastaging status.

Molecular tumor profiling is recommended and may be used to guide recommendations for adjuvant therapy.
About the Guideline

The guideline was based on a systematic literature review of articles published through August 2021. The multidisciplinary task force of subject matter experts included radiation oncologists, medical oncologists and gynecological oncologists, a medical physicist, a radiation oncology resident and a patient representative. The guideline was developed in collaboration with the American Brachytherapy Society, the American Society of Clinical Oncology and the Society of Gynecologic Oncology. It is endorsed by the Canadian Association of Radiation Oncology, European Society for Radiotherapy and Oncology, and the Royal Australian and New Zealand College of Radiologists.

The guideline also acknowledges the negative impact of systemic racial disparities on endometrial cancer outcomes. While the guideline is focused on the medical considerations for treatment, the task force also wanted to recognize the complex nature of access to care for underserved patient populations.

ASTRO's clinical guidelines are intended as tools to promote appropriately individualized, shared decision-making between physicians and patients. None should be construed as strict or superseding the appropriately informed and considered judgments of individual physicians and patients.

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