Five Minutes in Healthcare - Dr. John Santini

by Philip F. Jacobus, CEO | August 04, 2025

Dr. John Santini

Five Minutes in Healthcare is where I discuss current events with some of the industry's most influential leaders.

Today I am joined by Dr. John Santini, founder and CEO of Vergent Bioscience, a clinical-stage biotechnology company, to discuss the ways his company is working to improve cancer surgery by helping surgeons see lung tumors in the operating room.

The company is preparing for an upcoming Phase 3 trial of abenacianine for injection (VGT-309) in patients undergoing surgery for proven or suspected lung cancer. Abenacianine is designed to target and illuminate cancerous tissue to help surgeons see previously undetected or difficult-to-find tumors in real time.

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During our chat, we look at how this technique compares with other common approaches to surgical guidance, the history of abenacianine, and the reasons why John is optimistic that this tool will have applications across a range of tumors beyond lung cancer.

We hope you enjoy the conversation.

Please tell us what you think, and let us know who you would like to see interviewed next.

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About Phil Jacobus

Phil Jacobus has been involved in health care since 1977, when he visited China to sell equipment. He has done business in 35 countries and still travels extensively. Phil is active in charity, helps rural clinics and always tries to help DOTmed users when he can.

Phil is a member of AHRA, HFMA, AAMI and the Cryogenic Society of America. He has contributed to a number of magazines and journals and has addressed trade groups.

Phil's proudest achievement is that he has been happily married to his wife Barbara since 1989, who helped him found DOTmed in 1998.



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