"The launch of ColonRing in the United States is an exciting and important milestone for NiTi," said Itay Itzhaky, chief executive officer of NiTi Surgical Solutions. "With our global reach, fully integrated operations, and commitment to innovation, we have a unique opportunity to be the technology leader in bowel anastomosis as we continue to develop a broad portfolio of CE-marked and FDA-cleared surgical devices for tissue reconnection. We are committed to advancing BioDynamix Anastomosis to provide surgeons with a safer, more effective, and easier method of addressing the challenges of gastrointestinal surgery."

About ColonRing™ with BioDynamix™ Anastomosis Technology


NiTi Surgical Solutions has leveraged the features of Nitinol in the ColonRing technology. In the ColonRing, the Nitinol leaf springs stretch to open the ring for placement in the bowel, and then gradually return to their original closed position, adapting to variations in tissue thickness and accommodating compressed tissue. The Nitinol leaf springs continuously apply constant force range of pressure around the full circumference of the anastomosis. As the compression progresses over several days, the tissue trapped within the ring becomes necrotic, while healthy tissue is generated along the ring's outer perimeter.

In human trials and clinical practice, BioDynamix Anastomosis technology has shown the potential to provide durable anastomosis with encouraging results in the rate of complications, particularly in low cases. Colonoscopic examination at six months demonstrated a satisfactory and seamless anastomosis. In animal trials, ColonRing resulted in a time zero anastomotic burst strength up to three times stronger than circular staplers. In addition, histologic examination of resected anastomoses showed complete reepithelialization of the mucosa and a uniform anastomosis showing full recovery to the natural multi-layer tissue structure.

About NiTi™ Surgical Solutions

NiTi Surgical Solutions is focused on the BioDynamix™ of natural healing, offering state-of-the-art medical devices to optimize surgical outcomes for patients and physicians. NiTi Surgical Solutions currently markets its novel ColonRing™ device - the next generation of closure technology for colorectal resection - providing surgeons with a potentially safer and more effective alternative to standard staple-dependent closure techniques. NiTi continues to expand its core competencies and innovative technology to a variety of advanced surgical products, techniques, and procedures. NiTi Surgical Solutions is a privately held, venture backed company with headquarters in Israel and the U.S. The company's investors include Alice Ventures, Evergreen Venture Partners, Israel Healthcare Ventures, MMT Funds and SCP Vitalife. For more information, please visit www.nitisurgical.com.

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