dismiss

Clean Sweep Live Auction on Wed. February 27th. Click to view the full inventory

DOTmed Home MRI Oncology Ultrasound Molecular Imaging X-Ray Cardiology Health IT Business Affairs
News Home Parts & Service Operating Room CT Women's Health Proton Therapy Endoscopy HTMs Mobile Imaging
SEARCH
Current Location:
>
> This Story


Log in or Register to rate this News Story
Forward Printable StoryPrint Comment
Advertisement

 

advertisement

 

Molecular Imaging Homepage

Dennis Durmis MITA names chair of board of directors

Researchers find new PET tracer that better detects melanoma than 18F-FDG 18F-P3BZA could become the new gold standard

RadioMedix scores $2 million contract for Targeted Alpha-emitter therapy Treatment for neuroendocrine tumors

FDA clears United Imaging's total-body PET scanner Creating 3D images of entire human body in 15-30 seconds

FDA clears MIM SurePlan molecular radiotherapy software Can measure the absorbed dose from MRT for individual patients

Rob Beanlands ASNC names president for 2019

Former South African nuclear executives to appeal suspensions in court Involves monthslong shutdown of NTP Radioisotopes medical isotope plant

FDA grants Fast Track designation to 64-Cu-Dotatate Used in PET diagnostic exams for suspected neuroendocrine tumors

Editorial takes aim at NRC efforts to lower the bar for nuclear medicine providers 'The NRC has abdicated its role as a protection agency for patients' say authors

Progenics Pharmaceuticals selects Curium as European distributor of PyL Imaging agent for visualizing prostate cancer

Diseased mouse with atherosclerosis
viewed with optical and PET/CT imaging

PET/CT probe detects clogged arteries before atherosclerosis symptoms

by John W. Mitchell , Senior Correspondent
For the first time ever, a dual optical and PET/CT activity probe has identified clogged arteries in mice before the onset of atherosclerosis symptoms — a discovery made possible by the ability to target and image proteases, cells that are secreted by the agents which cause the disease.

"Atherosclerosis is one such disease where proteases are activated during inflammation and this activity is important for the pathology of the disease," Matthew Bogyo, Ph.D, one of the lead authors and professor in the Department of Pathology at Stanford University School of Medicine told HCB News. "My lab has been working on small molecule probes of proteases for a long time."

Story Continues Below Advertisement

Has exclusive distribution agreement with DDD to sell new Camera systems

UMRi provides the very best new & refurbished gamma cameras, quality parts &repair services. We also rebuild & replace camera detectors, move camera systems across town or across the country. Call us at 888-239-3510



Those with a build-up of plaques in their arteries can go decades with no symptoms. The disease often does not announce itself until a stroke or heart attack occurs. Bogyo said their research in mice could eventually lead to diagnostic protocols to identify people who are at high risk for cardiovascular events.

"We hope that this reagent (probe) could be validated in human clinical trials soon and be used to specifically highlight ‘vulnerable’ plaques that are likely to rupture due to inflammation," said Bogyo.

The team's study was just published in the October issue of The Journal of Nuclear Medicine.

According to Bogyo, the team found that the probe — which is dual labeled with a fluorescent reporter and a radioactive tag that can be used for whole body non-invasive imaging — binds itself to the proteases at the site of inflammation in arteriosclerotic plaques.

"We demonstrated that this probe could be used to monitor plaques in a mouse model of the human disease," explained Bogyo. "It also could be used to label plaques isolated from human patients with atherosclerosis, confirming that the reporter works in humans."

The study demonstrated that targeting the proteases offers a rapid, non-invasive way to image atherosclerotic disease progression and plaque vulnerability. He sees broader uses for the probes in the future. This includes the ability to allow specific targeting of disease-associated proteins or markers that allow monitoring of disease onset, progress and response to therapeutic agents.

“The probes show efficacy in a variety of imaging modalities, including fluorescence, PET/CT, and topical application of the probe to fresh frozen murine and human tissue sections," said Bogyo.

Molecular Imaging Homepage


You Must Be Logged In To Post A Comment

Advertise
Increase Your
Brand Awareness
Auctions + Private Sales
Get The
Best Price
Buy Equipment/Parts
Find The
Lowest Price
Daily News
Read The
Latest News
Directory
Browse All
DOTmed Users
Ethics on DOTmed
View Our
Ethics Program
Gold Parts Vendor Program
Receive PH
Requests
Gold Service Dealer Program
Receive RFP/PS
Requests
Healthcare Providers
See all
HCP Tools
Jobs/Training
Find/Fill
A Job
Parts Hunter +EasyPay
Get Parts
Quotes
Recently Certified
View Recently
Certified Users
Recently Rated
View Recently
Certified Users
Rental Central
Rent Equipment
For Less
Sell Equipment/Parts
Get The
Most Money
Service Technicians Forum
Find Help
And Advice
Simple RFP
Get Equipment
Quotes
Virtual Trade Show
Find Service
For Equipment
Access and use of this site is subject to the terms and conditions of our LEGAL NOTICE & PRIVACY NOTICE
Property of and Proprietary to DOTmed.com, Inc. Copyright ©2001-2019 DOTmed.com, Inc.
ALL RIGHTS RESERVED