• Globally, mortality rates declined more for women under 50 than for women over 50. Pizot said this reflects the fact that younger women tend to receive more intense treatments (such as longer courses of chemotherapy) which prolong their survival and may defer breast cancer death in older ages.
• Pizot said that the role of breast cancer screening is not clearly apparent in mortality trends. She said the study revealed several cases where nations with similar geographic locations and socioeconomic status experienced similar trends, no matter whether the country has used mammography screening since the 1980s or whether mammography was introduced in 2005 or later.
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“This finding underlines the difficulty of isolating a single, common factor that would have a major influence on mortality trends,” Pizot said, adding that future research on breast cancer mortality should focus on other facets of breast cancer management, including risk factors, drug therapies, access to care, and the use of multidisciplinary teams.
“Differences in health care systems and patient management could explain discrepancies in mortality reduction between similar countries,” Pizot said. “However, there is at present little data comparing the management of breast cancer patients across countries.”
Pizot said a limitation of the study is that data were unavailable for many Latin American, Asian, and African nations.
This study was funded internally by the International Prevention Research Institute. Pizot has no conflicts of interest.
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