June 22, 2017 – Cancer Research UK today (Thursday) launches the second phase of its global Grand Challenge by announcing eight new questions* – identified as some of the biggest barriers to making progress against cancer – and inviting the world’s top scientists to come together with new proposals to tackle them.

Grand Challenge - the most ambitious cancer research grant in the world - is a series of £20million awards over five years. The funding provides international research teams the freedom and incentive to try new approaches, at large scale, to pursue life changing discoveries.

Understanding the biology and genetics of cancer, and how to better prevent, diagnose and treat the disease are all areas covered by the eight questions.
International collaborations will be asked to:
• Devise approaches to prevent or treat cancer based on mechanisms that determine tissue specificity of some cancer genes
• Create novel tumour vaccinology approaches that establish or enhance successful immune responses beyond what is revealed by current checkpoint therapy
• Define mechanistic rules for combinatorial treatments to overcome resistance and avoid toxicity
• Distinguish between lethal cancers which need treating, and non-lethal cancers that don’t
• Identify and target tumour cells that remain dormant for many years after seemingly effective treatment
• Detect cancer earlier by interrogating medical and non-medical data sets using machine and deep-learning
• Improve treatment responses by manipulating the composition and status of the microbiota
• Determine the mechanisms that cause cancer without known mutagenesis, such as obesity, in order to devise novel interventions

Grand Challenge is calling for teams made up of researchers from different countries, backgrounds and disciplines to use their combined knowledge to solve these monumental problems.

In 2016 during the first phase, nine pioneering teams were shortlisted from 56 bids, against seven Grand Challenges.

The Independent Scientific Advisory Panel** were so excited by the world class potential of the shortlisted teams, they felt passionately that more than one needed to be funded.

With the generous support of an international philanthropist and another European research funder*** four remarkable teams**** were selected as the inaugural Grand Challenge recipients – each receiving up to £20m funding over five years.

Now, with eight new challenges set, researchers will have six months to assemble teams and submit outline proposals before the shortlisted teams are announced in the autumn.

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