In less than 1 week! Our Clean Sweep Auction on August 2nd at 9:30AM EDT goes LIVE

DOTmed Home MRI Oncology Ultrasound Molecular Imaging X-Ray Cardiology Health IT Business Affairs
News Home Parts & Service Operating Room CT Women's Health Proton Therapy Endoscopy HTMs Mobile Imaging
Current Location:
> This Story

Log in or Register to rate this News Story
Forward Printable StoryPrint Comment


Molecular Imaging Homepage

Researchers develop new PET/CT technique to more accurately diagnose cardiac sarcoidosis Can spot the disease in other organs as well

PET scans could improve dementia diagnosis in two-thirds of patients 'A swift and accurate diagnosis has a huge impact on access to Alzheimer's treatments.'

Siemens gets FDA nod for its Biograph Horizon Flow edition PET/CT Marketed as a "cost-competitive" system

German researchers develop new PET tracer for detecting blood clots Could help inform smarter use of anticoagulants

SPECT and SPECT/CT Product Showcase Check out some of the latest innovations from the leading manufacturers

The Future of nuclear medicine: Driving value in expanded clinical use Kees Wesdorp and Kirill Shalyaev examine the ways scientific breakthroughs translate into lives — and money — saved

New optimism regarding the supply of Moly-99 The workhorse SPECT isotope will not run out any time soon: Experts

PET/CT, PET/MR and PET Product Showcase A quick look at all the leading modalities in the market

How fast will the U.S. market get access to Gallium-68? The nuclear medicine world is preparing for the introduction of Ga-68 tracers

Purchasing insights: Molecular imaging modalities will grow in the coming years What to look for when your facility is investing in new systems

Gadolinium may become
a thing of the past

Researchers develop metal-free MR contrast agent for high-risk patients

by Lauren Dubinsky , Senior Reporter
Researchers at MIT and the University of Nebraska have developed a metal-free MR contrast agent that could be a safer option for high-risk patients.

"This is an entirely organic, metal-free MRI contrast agent that would allow cancer researchers to start to think about how to image tumors in a dynamic way over long periods of time," Jeremiah Johnson, professor at MIT, said in a statement.

Story Continues Below Advertisement

CT, MRI, NM, SPECT/CT, PET & PET/CT service, refurbished systems and parts

Accelerate your ROI with our Black Diamond Certified refurbished systems. One year warranty - ISO 13485 Certified - FDA registered - Over 65k parts in inventory DOTmed Certified

The most common MR contrast agents are based on the metal gadolinium, which cannot be used in patients with certain types of kidney problems.

The agent has also been under scrutiny lately due to research that showed it is retained in the brain. As a result, there has been an increasing interest in developing alternatives.

Scientists have tried to create non-metal agents such as organic radicals, which are compounds with unpaired electrons. They are usually broken down in the bloodstream within minutes and they don't produce as much MR contrast as metal agents.

In a paper recently published in ACS Central Science, Johnson and his colleagues described how they were able to manipulate the radicals into nitroxide brush-arm star polymer nanoparticles that can last in the bloodstream for up to 20 hours.

They demonstrated that it's a long enough time span to accumulate in a tumor in mice and that the nanoparticles are not harmful to mice even at very high doses.

Johnson envisions that these nanoparticles can be designed to carry drugs as well as an MR contrast agent. That would allow clinicians to monitor a tumor in the long term to determine if the drug is working.

He is also working with researchers at MIT's Koch Institute for Integrative Cancer Research to attach the contrast agent particles to antibodies that would help target specific cells for imaging and potentially, drug delivery.

Molecular Imaging Homepage

You Must Be Logged In To Post A Comment

Increase Your
Brand Awareness
Auctions + Private Sales
Get The
Best Price
Buy Equipment/Parts
Find The
Lowest Price
Daily News
Read The
Latest News
Browse All
DOTmed Users
Ethics on DOTmed
View Our
Ethics Program
Gold Parts Vendor Program
Receive PH
Gold Service Dealer Program
Receive RFP/PS
Healthcare Providers
See all
HCP Tools
A Job
Parts Hunter +EasyPay
Get Parts
Recently Certified
View Recently
Certified Users
Recently Rated
View Recently
Certified Users
Rental Central
Rent Equipment
For Less
Sell Equipment/Parts
Get The
Most Money
Service Technicians Forum
Find Help
And Advice
Simple RFP
Get Equipment
Virtual Trade Show
Find Service
For Equipment
Access and use of this site is subject to the terms and conditions of our LEGAL NOTICE & PRIVACY NOTICE
Property of and Proprietary to DOTmed.com, Inc. Copyright ©2001-2017 DOTmed.com, Inc.