DOTmed Home MRI Oncology Ultrasound Molecular Imaging X-Ray Cardiology Health IT Business Affairs
News Home Parts & Service Operating Room CT Women's Health Proton Therapy Endoscopy HTMs Mobile Imaging
SEARCH
Current Location:
>
>
> This Story

Forward Printable StoryPrint Comment

 

 

Cardiology Homepage

Study validates safety and pace of stroke thrombolysis response for Helsinki hospital

Stryker receives FDA pre-market approval for Surpass Streamline Flow Diverter to treat large and giant unruptured aneurysm

CardioFocus announces full commercial launch of HeartLight System in Japan

Abbott receives FDA approval for next-generation MitraClip device to treat people with leaky heart valves

iSchemaView brings RAPID imaging platform to Australia and New Zealand Through Exclusive Distributor, Diagnostic Imaging Austra

Zebra Medical Vision announces FDA clearance of its coronary calcium algorithm

USPSTF releases new recommendations for CVD and PAD

Cardiac hybrid imaging an effective tool for predicting heart attacks

Northwestern Medicine launches new center using AI and machine learning to treat cardiovascular disease

Edwards comments on CMS initiation of national coverage analysis for TAVR

Cell marking opens up a window into the body

Press releases may be edited for formatting or style
A new and particularly reliable method for marking cells can simplify research into diseases such as myocardial infarction, diabetes or Alzheimer's and reduce the use of test animals: Scientists from the University of Tübingen have developed a method by which they can target specific cell types in mice and monitor their behavior using positron emission tomography (PET). PET-based cell tracking allows scientists to observe complex life processes in the body without subjecting test animals to invasive methods.

"The ability to actively observe the behavior of selected cell populations in vivo without invasive methods opens up new avenues for research, detection and treatment of diseases. At the same time, it reduces the burden and number of animals required in comparison to previous methods," explains Professor Robert Feil. Professor Feil and his team from the Interfaculty Institute of Biochemistry (IFIB) at the University of Tübingen conducted the study together with the Werner Siemens Imaging Center and the Departments of Cardiology, Pathology and Physiology at University Hospital Tübingen and researchers in Nuclear Medicine at the Münster University Hospital. Their results have now been published in the journal Nature Communications.

Story Continues Below Advertisement

Servicing GE Nuclear Medicine equipment with OEM trained engineers

We offer full service contracts, PM contracts, rapid response, time and material,camera relocation. Nuclear medicine equipment service provider since 1975. Click or call now for more information 800 96 NUMED



Tissues and organs consist of many different cell types, such as blood, bone, liver, muscle or nerve cells. The migration or change in the number of specific cell types is a normal process in the body, but is also linked to many diseases. For example, the proliferation and migration of immune cells leads to inflammation, uncontrolled cell growth triggers cancer or arteriosclerosis and the loss of certain cell populations is the cause of diabetes mellitus or Alzheimer's disease. These processes are based on complex interactions of different cell types. In order to understand them, the entire organism must be studied.

The new cell tracking method is based on an artificial PET reporter enzyme, which can be produced by a genetic trick in each cell type of the mouse (for example, only in T-cells of the immune system). The enzyme

causes a radioactive substance, the PET tracer, to accumulate in these specific cells. The radiation is harmless to the animal and can be detected with a positron emission tomograph and shown on screen. The PET method has been used in humans for a long time and as a non-invasive procedure, it causes less burden than other diagnostic methods.

Until now investigating cell behavior in mice necessitated stressful or harmful procedures which are only suitable for a few cell types or may require the sacrifice of experimental animals. "By using modern imaging techniques, we can achieve a reduction in the number of test animals by up to 80 percent," says Dr. Martin Thunemann, first author of the study, who is now researching at the University of California in San Diego. "The marked cell populations can be monitored non-invasively in living mice for many weeks, so that the same group of animals can be examined repeatedly." In the study, the authors marked blood platelets, myocardial cells, or T cells in experimental mice, and then followed their behavior in myocardial infarction or inflammatory reactions.
  Pages: 1 - 2 >>

Cardiology Homepage


You Must Be Logged In To Post A Comment

Advertise
Increase Your
Brand Awareness
Auctions + Private Sales
Get The
Best Price
Buy Equipment/Parts
Find The
Lowest Price
Daily News
Read The
Latest News
Directory
Browse All
DOTmed Users
Ethics on DOTmed
View Our
Ethics Program
Gold Parts Vendor Program
Receive PH
Requests
Gold Service Dealer Program
Receive RFP/PS
Requests
Healthcare Providers
See all
HCP Tools
Jobs/Training
Find/Fill
A Job
Parts Hunter +EasyPay
Get Parts
Quotes
Recently Certified
View Recently
Certified Users
Recently Rated
View Recently
Certified Users
Rental Central
Rent Equipment
For Less
Sell Equipment/Parts
Get The
Most Money
Service Technicians Forum
Find Help
And Advice
Simple RFP
Get Equipment
Quotes
Virtual Trade Show
Find Service
For Equipment
Access and use of this site is subject to the terms and conditions of our LEGAL NOTICE & PRIVACY NOTICE
Property of and Proprietary to DOTmed.com, Inc. Copyright ©2001-2018 DOTmed.com, Inc.
ALL RIGHTS RESERVED