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Molecular Imaging Homepage

SHINE completes Building One of medical isotope production facility Facility is projected to become domestic source for Mo-99 production in US

Ian Wilson ImaginAb appoints chief operating officer

Study finds patients lack info about imaging exams Researchers uncover what they want to know

Philips to invest in new R&D facility in Cleveland, Ohio Will also cease manufacturing operations there

Danish university installs MILabs PET/SPECT/CT system Will be used to investigate neuronal disorders on the basis of glial biology

NorthStar to be first U.S. source of Mo-99 in more than 25 years First production process using non-uranium-based Mo-99

Study finds PSMA PET/CT can identify early prostate cancer recurrence Already a standard in Europe

Curium now manufacturing radio-pharmaceuticals with low-enriched uranium First in North America to make full transition

The five most important questions to ask about SPECT service Insights from Craig Snodgrass, national service manager at Universal Medical

The New York Times moly-99 report: 6 takeaways Insights from several experts on the delicate moly-99 supply chain

UAlberta researchers in the lab

Two new imaging agents may help physicians make better and quicker treatment decisions

by Lauren Dubinsky , Senior Reporter
Two new imaging agents may help physicians personalize cancer therapy and determine a patient's response to a drug 24 hours after it's administered.

These imaging agents can be used with PET and fluorescence imaging to visualize the formation of tumor-associated blood vessels and track tumor growth.

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Researchers at the University of Alberta in Canada worked with colleagues at Western University and Case Western Reserve University to develop the imaging agents. They investigated a protein called EGFL7 that is specific to actively growing blood vessels.

The team started by creating peptides that attach to EGFL7 proteins in order to determine if they would be useful for imaging applications. PET exams using the peptide were performed on mice with tumors in order to localize the tumors and illuminate them.

They also used the peptide to create nanoparticles and those were shown to accumulate in the new blood vessels and illuminate as well.

Many cancer drugs on the market inhibit the formation of new tumor-related blood vessels, but it's difficult to determine which patients would benefit from them. They can be toxic for one patient and lifesaving for another.

The team believes that these new imaging agents can provide physicians with the information they need to make more personalized treatment decisions.

The agent can be used prior to treatment in order to see how many blood vessels are forming. That would determine whether an individual patient is a candidate for those drugs.

The agents can also be used during treatment to monitor their response to therapy. Traditionally, physicians measure changes in tumor size up to a month after treatment, but this new method could determine that in 24 hours.

The next step is to test the imaging agents in a treatment setting. The researchers will initially perform experiments on animal models and then move on to clinical work.

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