According to the Centers for Disease Control and Prevention, colorectal cancer is the third most common cancer affecting both men and women. Each year, approximately 140,000 new cases are diagnosed in the United States and 50,000 people die of the disease.

The applications of this nuclear medicine treatment protocol could extend to other cancers as well. Larson and Cheal state, "If clinically successful, our approach will expand the repertoire of effective treatments for oncologic patients. The system is designed as a 'plug and play' system, which allows for the use of many fine antibodies targeting human tumor antigens and is applicable, in principle, to virtually all solid and liquid tumors in man." They add, "There is a huge unmet need in oncology, especially for the solid tumors, for curative treatments for advanced disease. This includes, colon, breast, pancreas, melanoma, lung, and esophageal, to name a few."


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Authors of "Curative multicycle radioimmunotherapy monitored by quantitative SPECT/CT-based theranostics, using bispecific antibody pretargeting strategy in colorectal cancer" include Sarah M. Cheal, Edward K. Fung, Mitesh Patel, Hong Xu, Hong-fen Guo, Pat B. Zanzonico, Nai-Kong V. Cheung, and Steven M. Larson of Memorial Sloan Kettering Cancer Center, New York, NY; Sebastien Monette of the Tri-Institutional Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, and The Rockefeller University, New York, NY; and K. Dane Wittrup, Massachusetts Institute of Technology, Cambridge, MA.

This study was supported in part by the Donna & Benjamin M. Rosen Chair; Enid A. Haupt Chair; The Center for Targeted Radioimmunotherapy and Theranostics, Ludwig Center for Cancer Immunotherapy of Memorial Sloan Kettering Cancer Center; NIH R01 CA101830, and NIH/NCI Cancer Center Support Grant P30 CA008748. S.M. Larson was also supported in part by NIH P50 CA86438.

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Please visit the SNMMI Media Center to view the PDF of the study, including images, and more information about molecular imaging and personalized medicine.

About the Society of Nuclear Medicine and Molecular Imaging

The Society of Nuclear Medicine and Molecular Imaging (SNMMI) is an international scientific and medical organization dedicated to raising awareness about nuclear medicine and molecular imaging, vital elements of precision medicine that allow diagnosis and treatment to be tailored to individual patients in order to achieve the best possible outcomes.

SNMMI's more than 15,000 members set the standard for molecular imaging and nuclear medicine practice by creating guidelines, sharing information through journals and meetings and leading advocacy on key issues that affect molecular imaging and therapy research and practice.

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