Also, a pulsed electron paramagnetic resonance/X-band electron nuclear double resonance spectrometer will be purchased by the University of Washington in Seattle, to study the function of enzymes, structural proteins, and proteins at DNA and RNA interfaces.

Another award will support the University of California, San Diego, in its purchase of a high-performance, intermediate voltage transmission electron microscope to enable 3-D imaging of sections of cells and biological tissues. Also funded is a confocal imaging system at the University of Maryland Biotechnology Institute in Baltimore, to enable the study of calcium signaling in living cells, as well as investigations involving neuronal and brain slice imaging.


At the University of Wisconsin School of Medicine and Public Health in Madison, positron emission tomography tracer development and production equipment will be purchased to facilitate research involving cancer, neuroscience, cardiovascular, and regenerative medicine. Finally, new state-of-the-art DNA sequencing instrumentation will be acquired by Yale University in New Haven, Conn., to assist investigations involving epilepsy, psychiatric disorders, autism, cardiovascular disorders, and cancer.

For more details on the High-End Awards, please click here

In order to qualify for a HEI award, institutions must identify three or more NIH-funded investigators whose research requires the requested instrument. Matching funds are not required for these grants, which provide a maximum of $2 million each. However, institutions are expected to provide an appropriate level of support for associated infrastructure, such as building alterations or renovations, technical personnel, and post-award service contracts for instrument maintenance and operation.

More information about the High-End Instrumentation program, including application guidelines, is available here.

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