"The recognition that a significant fraction of patients harbor greater than 10 percent tumor DNA in blood suggests that liquid biopsies may enable routine and non-invasive profiling of cancer genomes for patients with metastatic TNBC," says Viktor Adalsteinsson, PhD, co-corresponding author and group leader of the Blood Biopsy Team at the Broad Institute.
Researchers say this study suggests that minimally invasive liquid biopsies could be used as a new predictive marker for metastatic TNBC.
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"This is a very challenging disease. Our team's findings -- and others enabled by liquid biopsy --could improve how we track disease and treat our patients in the clinic," says Heather Parsons, MD, MPH, co-first author of the study and breast medical oncologist/researcher at Dana-Farber Cancer Institute and Harvard Medical School.
"These are exciting and important discoveries that could help us understand how a patient's cancer is likely to progress and, ultimately, could have the potential to guide treatment decisions based on specific genomic risk factors," adds Stover, whose plans for his laboratory at the OSUCCC - James include expanded validation studies with a goal to bring this test into the clinic and investigate new methods to study circulating DNA.
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