The study confirms the MAC phenomenon but more importantly, shows that through Cell-CT platform imaging, it can be reliably detected.
“The study findings have important implications for how cancer detection is managed with the Cell-CT platform. Detection of MAC could be used to alert cytology staff of likely abnormal conditions – a feature that may be especially important in detecting early stage cancers”, said Alan C. Nelson, PhD, Chairman and CEO.

Importantly, this capability could further boost LuCED lung test’s sensitivity, reduce the potential for false positive tests and improve the efficiency of our laboratory operations by reducing specimen processing time and workload”, Dr. Nelson added.


This study was done using patient sputum from normal and lung cancer patients. Further work will develop the MAC detection feature set and emphasize results at the case rather than cellular level. Moreover, we may be able to detect minor, but significant changes in cancer progression and therapy response that are not perceivable by human visual review. VisionGate envisions further potential applications based on additional liquid biopsy specimens for detection of other cancers.

The abstract details are:

Title: The Malignancy Associated Change Hypothesis Tested Through 3D Cellular Imaging

Presentation Number: Abstract #LB-175

Session: Late-Breaking Research: Epidemiology and Prevention

Date and Time: Monday, April 16, 2018, 1:00 p.m. – 5:00 p.m. CDT, Chicago

Location: Poster Section 44, Poster Board 18

Full session details and data presentation listings for AACR 2018 can be found at: http://www.abstractsonline.com/pp8/#!/4562

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About VisionGate, Inc.

VisionGate is a clinical stage oncology pharmaceutical and diagnostics company focused on the early detection and prevention of cancer. Our lead investigative pharmaceutical drug is oral iloprost, currently in clinical development for the treatment of pre-cancerous bronchial dysplasia and the prevention of lung cancer following a successful Phase 2 clinical trial. The LuCED® lung test will be the companion diagnostic for oral iloprost. VisionGate’s proprietary LuCED lung test is a non-invasive liquid biopsy diagnostic test in development for detection of early-stage lung cancer, demonstrating exquisite sensitivity and specificity in blinded clinical studies. This non-invasive sputum test is processed on the world’s first automated 3D single cell imaging and analysis technology, the Cell-CT™ platform, named aptly because it is similar in principle to taking a CT scan of individual cells, but using visible light without harmful radiation. With 176 issued patents in 13 countries, VisionGate expects to play a leading role in the battle against lung cancer - the world’s number one cancer killer. VisionGate, Inc. is led by Dr. Alan Nelson, physicist, bioengineer, and serial entrepreneur who previously developed the world’s first and only automated screening test to detect cervical cancer, marketed globally today as FocalPoint by Becton Dickinson. The LuCED lung test is a product in development and is not currently available commercially.

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