SUNNYVALE, Calif., May 30, 2018 /PRNewswire/ -- Accuray Incorporated (NASDAQ: ARAY) announced today that recently published data from two new studies demonstrate the benefits of the TomoTherapy® System in the delivery of total body irradiation (TBI), a procedure commonly used to prepare patients being treated for leukemia and multiple myeloma for a bone marrow transplant. TBI involves irradiation of the entire body, elevating the need for precision, accuracy and homogeneity in radiation dose delivery. The TomoTherapy platform's unique architecture enables efficient and extremely effective delivery of radiation over large areas of the patient, making it a valuable part of the bone marrow transplantation conditioning regimen.
In TBI treatments, radiation is administered to the patient as part of a multimodality treatment regimen, typically in combination with high dose chemotherapy. The irradiation contributes to the eradication of malignant cells, especially those that are chemotherapy-resistant or in sites not easily reached by chemotherapy drugs. TBI also helps prevent the body's immune system from rejecting the healthy donor cells after the transplant.
The TomoTherapy platform, including the next-generation Radixact® System, has continuous gantry rotation and couch motion that enables helical delivery of therapy (TomoHelical™). This treatment modality produces intensity-modulated radiation from 360 degrees around the patient over very long treatment fields, which significantly enhances the ability to achieve homogenous dose distributions for TBI, while also simplifying and streamlining the treatment delivery process. TBI treatments on conventional systems have been shown to pose a greater risk of over-dosing some areas and under-dosing others. Over-dosing may lead to toxicity and under-dosing means that the goal of eradicating the tumor cells is less likely to be achieved.
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Study Highlights
Precise and homogeneous tumor coverage across the entire treatment area
In one study, the clinical team from IUCT Oncopole in Toulouse, France shared results of their clinical experience with TomoHelical in a study titled, "Total body irradiation using Helical TomoTherapy®: Treatment technique, dosimetric results and initial clinical experience," published in the February 2018 issue of the journal Cancer/Radiothérapie. They found:
The TomoTherapy platform enabled treatment of the entire body in only two segments, the upper body and the lower body. A highly conformal and homogeneous dose distribution was achieved throughout the body including at the junction between the upper and lower body fields
