This study laid the groundwork for a phase 1 clinical trial (NCT03423628) led by AstraZeneca that will test AZ1390 in combination with radiation therapy for the treatment of brain tumors. It will assess the safety and tolerability of increasing doses of AZ1390 in combination with different regimens of radiation therapy for recurrent GBM, brain metastases and newly diagnosed GBM. The trial is estimated to enroll 132 patients at seven medical centers in the US and the UK, including VCU Massey Cancer Center.
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Valerie collaborated on this study with Jeremy Karlin, M.D., Jasmine Allen, Syed F. Ahmad, Amrita Sule, Ph.D., Laura Biddlestone-Thorpe, Ph.D., Jenna Kahn, M.D., Jason M. Beckta, M.D., Ph.D., Nitai Mukhopadhyay, Ph.D., and Nicholas C.K. Valerie, all from the Department of Radiation Oncology at VCU Massey Cancer Center; as well as Gareth Hughes, Victoria Sheridan, Rajesh Odedra, Paul Farrington, Elaine B. Cadogan, Lucy C. Riches, Antionio Garcia-Trinidad, Andrew G. Thomason, Bhavika Patel, Jennifer Vincent, Alan Lau, Kurt G. Pike, Thomas A. Hunt, Bernard Barlaam, Sebastien L. Degorce, Jason Kettle, Nicola Colclough, Joanne Wilson, Aaron Smith, Ian P. Barrett, Li Zheng, Tianwei Zhang, Yingchun Wang, Kan Chen, Martin Pass and Stephen T. Durant, all from AstraZeneca.
This study was supported by grants R01NS064593, R21CA194789 and R21CA156995 by the National Institutes of Health (NIH) and National Cancer Institute (NCI); AstraZeneca; and, in part, by VCU Massey Cancer Center's NIH-NCI Cancer Center Support Grant P30 CA016059.
Valerie collaborated on the AZD1390 study with Jasmine Allen, Jenna Kahn, M.D., Amrita Sule, Ph.D., and Jeremy Karlin, M.D., all from the Department of Radiation Oncology at VCU Massey Cancer Center; as well as Durant S., L. Zheng, Y. Wang, K. Chen, L. Zhang, T. Zhang, L. Riches, A. Garcia-Trinidad, T. Hunt, K.G. Pike, J. Wilson, A. Smith, N. Colclough, V.P. Reddy, A. Sykes, A. Janefeldt, P. Johnström, K. Varnäs, A. Takano, S. Ling, J. Stott, I. Barrett, G. Jones, A. Pierce, A. Cronin, M. Chapman, Z. Yang, R. Illingworth, M. Pass., from AstraZeneca and the Karolinska Institutet.
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