Noninvasive ultrasound stimulation of spleen could lead to new treatments for inflammatory arthritis

Noninvasive ultrasound stimulation of spleen could lead to new treatments for inflammatory arthritis

Press releases may be edited for formatting or style | March 15, 2019 Ultrasound
Researchers at the University of Minnesota, in collaboration with researchers at Medtronic, have shown that noninvasive daily ultrasound stimulation of the spleen in mice with inflammatory arthritis resulted in significantly less joint swelling compared to arthritic mice that were not treated. The research is a first step to developing new treatment options for more than a million people in the United States who currently suffer from rheumatoid arthritis.

The research is currently published in Nature Communications and has resulted in a University of Minnesota-led preliminary human clinical trial.

"What we found in our mouse study is that we could actually 'turn down' the inflammatory response with daily ultrasound stimulation of the spleen from outside the body," said Daniel Zachs, the first author of the study and a biomedical engineering researcher in the University of Minnesota's College of Science and Engineering. "We're hopeful that this type of noninvasive treatment could someday supplement current treatments for people with rheumatoid arthritis."

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Inflammatory arthritis is an autoimmune disease, which means that the body's immune system attacks healthy tissue in addition to germs, viruses and other foreign substances. This reaction can cause pain, stiffness, and joint damage. Current treatments usually include medicines that have a wide variety of side effects.

Researchers involved in this new study induced inflammatory arthritis in laboratory mice and then targeted the spleen with ultrasound stimulation for seven days following the injection. Some mice were treated only after the arthritis was evident on the third day. The mice that received the ultrasound treatment had significantly less joint swelling than arthritic mice that did not receive ultrasound stimulation.

"Using noninvasive ultrasound stimulation of the spleen to treat a progressive disease like inflammatory arthritis seemed like a far-fetched idea," said Hubert Lim, Ph.D., a senior author of the study and a University of Minnesota biomedical engineering associate professor in the College of Science and Engineering and the Medical School. "We were pleasantly surprised with our results and how a separate study, independently performed by GE Research and The Feinstein Institute for Medical Research published in the same issue of Nature Communications, showed findings that were consistent with our research."

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