The first dual PET isotope scans on live mice were performed this month with MILabs’ VECTor6 imaging system as part of a collaboration between Delft University of Technology, University Medical Center Utrecht and MILabs.
Ultra-high-resolution PET images were shown of a mouse to which Iodine-124 and NaF-18 was administered. MILabs discussed the breakthrough for the nuclear medicine community this weekend at the SNMMI 2019 Annual meeting in Anaheim.
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“You can look at the same time at different functions of tissue, Freek Beekman, founder of MILabs, told HCB News. “Several isotopes for therapy also send out photons you can see on the outside, and then you can measure how much radiation reaches the tumor. Then, you can have another tracer with an isotope that can measure the effect of the therapy, such as if the cells are dying.”
Being a tomographic system that can scan photons from one EV to one MEV, VECTor6 is the only system that can perform simultaneous multi-isotope PET and PET/SPECT scans in the market. A new technique is also available to eliminate blurring due to positron range so that the image is sharp.
While dual-isotope SPECT procedures have been around for a long time, performing them with PET was not possible. This dual-isotope PET technology, however, is at this time only suitable for preclinical research.
“Now we have dual-isotope PET data of a living organism,” said Beekman. “If people need to investigate PET tracers to later be translated to the clinic, they can strongly benefit from our versatile PET machine that can also perform quarter-mm resolution SPECT. With the theranostic revolution and for several other reasons, many of our clients find it important to have both SPECT and PET.”