BELOIT, Wis. – March 3, 2020 – NorthStar Medical Technologies, LLC, a global innovator in the production and distribution of radioisotopes used for medical imaging, today announced that it has entered into a worldwide, exclusive licensing agreement with Capella Imaging, LLC, a BioGenerator company focused on the development of diagnostic imaging agents to support unmet medical needs. Under the agreement, NorthStar has licensed exclusive rights to a fibrin-targeted diagnostic imaging agent for cardiac imaging. FibroScint (Tc-99m F4A) is a fibrin-targeted, peptide compound labeled with the radioisotope technetium-99m (Tc-99m) for SPECT imaging. If successfully developed and approved, it may have potential applications across multiple cardiovascular conditions such as thrombus (blood clots) associated with left ventricular assist devices (LVADs), deep vein thrombosis, pulmonary embolism and acute coronary syndrome. Initial clinical investigation of FibroScint will be an exploratory Phase 1 study for its potential use in identifying thrombus in patients with serious heart failure who use an LVAD. It is anticipated that the first indication for FibroScint will receive an Orphan Drug designation.

"This agreement aligns with NorthStar's strategic focus and further advances our mission to develop and commercialize radioisotope products to meet the needs of patients and advance clinical research," said Stephen Merrick, President and Chief Executive Officer of NorthStar Medical Technologies. "FibroScint is a unique diagnostic agent and an ideal addition to our portfolio which complements the commercially available RadioGenix® System (technetium Tc 99m generator). NorthStar intends to use Tc-99m produced by RadioGenix Systems in the planned clinical studies of FibroScint. We look forward to collaborating with Capella Imaging on further early development of this agent."

Under terms of the agreement, NorthStar will invest $1 million in Capella equity in conjunction with Capella seeking federal funding grants, both of which will be used for completion of Phase 1 clinical development through an exploratory Investigational New Drug application (eIND) for the LVAD indication. NorthStar has the option to make additional equity investment in support of future clinical trials and would make additional success payments to Capella contingent upon completion of certain regulatory and revenue milestones, with royalties payable upon commercialization of the product in each of three potential diagnostic indications. Further terms of the agreement were not disclosed.

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