Over 90 Total Lots Up For Auction at One Location - WA 04/08

Surgical delays for very early stage breast cancer not tied to worse survival outcomes

Press releases may be edited for formatting or style | August 07, 2020 Operating Room Women's Health
Beginning in March, as COVID-19 cases surged in various states in the U.S., the COVID-19 Pandemic Breast Cancer Consortium released recommendations that operations for ductal carcinoma in situ (DCIS) be deferred due to the pandemic. DCIS, which goes by many names including "stage 0" breast cancer, is a non-invasive form of cancer that begins in the milk ducts and is generally surgically excised. In approximately one in five cases, surgeons may find evidence of invasive cancer during surgery. During the pandemic, patients and clinicians expressed concern about what surgical delays might mean for patients' outcomes. A new study led by, investigators from Brigham and Women's Hospital, of more than 378,000 patients who were diagnosed with very early stage breast cancer between 2010 and 2016 offers new data and insights to help address these unknowns. The research team found that while increased time to surgery was associated with a small increase in pathological upstaging in DCIS patients, it did not impact overall survival. Results are published in the Journal of the American College of Surgeons.

"The most pressing question today is what will surgical delays due to the pandemic mean for patient outcomes, and the reality is that we will only have the answers years from now," said lead author Christina Minami, MD, MS, a surgeon in the Division of Breast Surgery at the Brigham. "In the meantime, these data should provide some reassurance and encouragement -- they don't indicate that outcomes will be changed dramatically. But we do encourage patients to follow up with their surgeons on a care plan as COVID-19 surges grow or subside locally."

Minami and colleagues leveraged data from the National Cancer Database for patients, which captures approximately 70 percent of newly diagnosed cancer in the U.S. All patients diagnosed January 1, 2010 to December 31, 2016 who underwent breast cancer surgery were identified. The team focused on patients with DCIS or early-stage (cT1-2N0) ER+ disease, an early form of breast cancer that may be susceptible to hormone therapy drugs.

More than 98 percent of patients with DCIS underwent surgery within three months. Among those who delayed surgery 60 days or longer, there was no significant difference in overall survival but there was a slight increase in upstaging. In patients with cT1-2N0 disease who were placed on neoadjuvant endocrine therapy -- a hormone therapy -- increased time to surgery did not impact stage or overall survival.

You Must Be Logged In To Post A Comment