New Orleans (Mar 05, 2023) - Patients with complex coronary artery disease who underwent a stenting procedure guided by intravascular imaging were nearly 40% less likely to die of heart disease, have a heart attack caused by a new blockage in the treated artery or need a repeat stenting procedure in the treated artery, compared with similar patients who underwent a standard angiography-guided stenting procedure, according to research presented at the American College of Cardiology’s Annual Scientific Session Together With the World Congress of Cardiology.
“Our study shows that the use of intravascular imaging devices to visualize the interior of narrowed coronary arteries improves outcomes after stenting,” said Joo-Yong Hahn, MD, PhD, professor of cardiology and medicine at Sungkyunkwan University School of Medicine in Seoul, South Korea, and lead author of the study.

The insertion of a stent (a tiny metal tube, usually coated with slow-release medication to help prevent repeat narrowing or blockage) into a coronary artery is a minimally invasive alternative to cardiac bypass surgery for people with a coronary artery that is blocked or partially blocked by a buildup of fatty deposits (plaque). Some types of coronary artery blockages, however, are more challenging to treat with stents. This may be because a blockage is unusually long, calcified or located in a difficult-to-reach spot such as near the junction of the coronary artery and the aorta. People with such complex coronary artery blockages are at increased risk for experiencing a heart attack or a blood clot in a stent or for needing a repeat stenting procedure.

Angiography (a heart X-ray) is the standard technique used to assess the extent of a patient’s arterial blockage and guide the stenting procedure. Intravascular imaging, an adjunctive invasive tool on top of angiography, generates images from inside a diseased artery that can provide clinicians with more detailed information about the blockage such as its exact location, size, thickness and composition. Two types of intravascular imaging are intravascular ultrasound (IVUS), which uses sound waves to visualize the artery’s interior, and optical coherence tomography (OCT), which uses infrared light. The most appropriate of these techniques for each patient may depend on characteristics of both the patient and their diseased artery, Hahn said.

The aim of the RENOVATE study was to determine whether the use of intravascular imaging in addition to angiography would lead to better outcomes, compared with angiography alone, in patients with complex coronary artery blockages. A total of 1,639 patients (median age 66, 20.7% women) were enrolled in the study at 20 centers in South Korea. Patients were randomly assigned to undergo stenting guided by either IVUS or OCT (with the choice of technique left to the clinician’s discretion) or a standard angiography-guided stenting procedure. The study’s primary endpoint was a combination of death due to heart disease, a heart attack caused by a new blockage in the treated artery or the need for a repeat stenting procedure in the treated artery.

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