March 6, 2017 – Advanced Oncotherapy (AIM: AVO), the developer of next generation proton therapy systems for cancer treatment, will be hosting investor and analyst presentations in London later today and in Zürich, Switzerland, the following day, Tuesday 7 March 2017.

The presentations will outline some of the key aspects of Advanced Oncotherapy's technology, the clinical benefits of proton therapy, the rationale for using linear accelerators and the key milestones for the manufacturing and commercialisation of LIGHT (Linac for Image Guided Hadron Therapy). These events are in relation to the initial 100 day review that has been conducted by CEO Nicolas Serandour, as announced upon his appointment on 27 October 2016.

The Company's focus remains on delivering the technical development of its first LIGHT machine and its installation at Harley Street, which is pivotal to its future strategy. The details of the manufacturing and commercialisation process of Advanced Oncotherapy's LIGHT system, including installation at the Harley Street site, will be discussed during the presentation and are provided in the update below:
Harley Street
As announced last month, Deconstruct (UK) Limited has been appointed by Howard de Walden Estates as principal contractor to the project and were on site in January carrying out preliminary assessment and works. Following the preparatory works, excavation is due to commence on 27 March 2017.

All necessary tendering processes have been completed. Based on initial quotes, on-site excavation and build times for the core and shell are estimated to take between 62 and 96 weeks. Additional time of up to 52 weeks will be required for full fit-out, including the installation of cooling systems and power supplies. The construction time reflects the constraints associated with two listed buildings (141 and 143 Harley Street) in a residential area. Yet it compares favourably to building times associated with the construction of multi-room proton beam facilities using legacy technologies traditionally built in large and remote areas, which is in the range of three to four years on average. The site is therefore expected to be ready for installation by H1 2019. Following regulatory approval and commissioning, the first patient treatment at Harley Street is expected in H2 2020.

Production manufacturing site
The Company's strategy is to establish a mass production facility, which will be ready for production once regulatory approval for the LIGHT system is granted. The Company continues to advance the arrangements with its manufacturing partner, Thales, to establish two custom designed series production lines for volume production at their factory in Thonon, France. The production facility is expected to be ready to receive LIGHT system components in Q1 2018, with all components due to be installed to create a LIGHT system operating at the maximum required energy ahead of the expected completion of the building in Harley Street in H1 2019.

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