A study of CyberKnife SBRT for oligorecurrent liver disease showed treatment was well-tolerated and resulted in favorable survival data. Clinicians at three European hospitals conducted the research.
A study evaluated the efficacy and toxicity of single fraction SBRT for isolated nodal failure in prostate cancer patients, after primary surgical or radiation treatment. Treatment with the CyberKnife System provided excellent tolerability and promising biochemical control at 13 months' follow-up. Research was conducted at three Italian hospitals.
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Metastatic Disease
A study of patients with solitary extracranial metastases from gynecologic malignancies demonstrated that SBRT delivered with the CyberKnife® System is well-tolerated and highly effective. An excellent 5-year local control of 93.7% was achieved in patients with classical ovarian and uterine primary tumors. Research was conducted at Georgetown University Hospital in Washington, DC.
Another study evaluated 206 patients with 326 inoperable pulmonary oligometastases, from colorectal tumors, lung cancers, melanoma, sarcoma, breast carcinoma, and from other sites, treated with SBRT. This long-term follow-up study showed good local control (83% at 2-years and 73% at 5-years) and overall survival (2, 3, and 5-year OS rates were 63%, 47% and 30%, respectively), as well as low rates of serious toxicity. Research was conducted at Erasmus MC-Daniel den Hoed Cancer Center in Rotterdam (The Netherlands).
Technical innovations improve the delivery of radiation therapy
New studies reinforce previous data demonstrating intracranial and extracranial treatments delivered using the CyberKnife System InCise™ Multileaf Collimator result in comparable target coverage and organ-at-risk sparing to the Iris™ Collimator, while significantly reducing treatment times (15% to 47% reduction compared to Iris plans depending on tumor type). Research was conducted at six European hospitals.
The first study to use three-dimensional performance analysis of the Synchrony® Respiratory Tracking System found it successfully tracks lung tumors regardless of the amplitude of movement. Research was conducted at Hacettepe University in Ankara, Turkey.
The CyberKnife System was designed to deliver treatment beams of different size and shape from hundreds of non-coplanar, isocentric or non-isocentric angles around the patient, enabling the clinician to deliver high-quality treatment plans with extreme precision, sparing surrounding healthy tissue and structures. The system's tracking capabilities eliminate the need for gating techniques and restrictive head frames, providing greater comfort for the patient.
