DOTmed Home MRI Oncology Ultrasound Molecular Imaging X-Ray Cardiology Health IT Business Affairs
News Home Parts & Service Operating Room CT Women's Health Proton Therapy Endoscopy HTMs Mobile Imaging
Current Location:
> This Story

Log in or Register to rate this News Story
Forward Printable StoryPrint Comment



Molecular Imaging Homepage

PET tracer may help assess promising Alzheimer's treatment Visualizing progress with 18F-AV45 PET imaging agent

New nanoparticle technology may replace MR for cancer detection Shows promise in preclinical study

US Nuclear Corp signs letter of intent to manufacture MIFTEC medical isotope generators Utilizes MIFTI's Staged Z-Pinch fusion technique

The five most important questions to ask about SPECT service Insights from Craig Snodgrass, national service manager at Universal Medical

Expert makes the case for patient access to radiology reports Patients want a more active role in their care

Cerveau signs research contract with UV Medical Center in Amsterdam For the manufacture and supply of PET agent MK-6240

MGH team develops a potential alternative to gadolinium-based contrast agents Made of the vital element manganese

Global PET/CT scanner market projected to reach $2.1 billion by 2023 Growth spurred in part by increased Medicare coverage

Can theranostics be the key to completely curing colorectal cancer? Preclinical trials yield promising results

Cerveau Technologies to collaborate in development of PET imaging agents for Alzheimer’s disease

The molecular structure of a
gold-based precursor used
for PET tracer synthesis,
determined by X-ray

Researchers discover mechanism to develop new PET radiotracers

by Lauren Dubinsky , Senior Reporter
New PET radiotracers may soon be coming down the pike, thanks to a chemical mechanism discovered by scientists at Berkeley Lab and UC Berkeley.

"Overall there are limited traditional organic chemistry mechanisms that are fast enough or scale well enough to allow efficient radiochemistry," James P. O'Neil, staff scientist and group leader at the Lawrence Berkeley National Laboratory, told HCB News.

Story Continues Below Advertisement

CT, MRI, NM, SPECT/CT, PET & PET/CT service, refurbished systems and parts

Accelerate your ROI with our Black Diamond Certified refurbished systems. One year warranty - ISO 13485 Certified - FDA registered - Over 65k parts in inventory

When studying chemical reactions of a gold-containing molecule, the research team stumbled upon a chemical mechanism that can be used to form trifluoromethyl (CF3) compounds and attach them to other chemical compounds.

This discovery could aid in the development of new classes of PET radiotracers that have previously been too difficult or even impossible to prepare.

"While substantial interest has been given lately to the trifluoromethyl group in the context of radiotracer development for PET, attempts to access this group by nucleophilic and electrophilic radio fluorination protocols date back to 1979," said O'Neil.

The new chemical mechanism that's based on the discovery in gold chemistry, allows the team to attach a radioactive fluorine atom to a specific class of molecule that was previously challenging to do.

Drug companies have been increasingly interested in incorporating CF3 compounds in a range of pharmaceuticals because it makes them more selective, effective or potent. The antidepressant Prozac, HIV drug Sistiva and anti-inflammatory Celebrex are a few drugs that contain CF3 compounds.

O'Neil noted that the pharmaceutical field and diagnostic medicine field have been very limited in getting compounds that have been labeled with radioactive CF3, but yet there are a lot of drugs that have CF3 in them.

The team hopes to partner with a group that has a specific biological target or drug candidate of interest that contains a CF3 compound to adapt the new mechanism to the specific application. They can then work on developing radiotracers that incorporate the compound.

Molecular Imaging Homepage

You Must Be Logged In To Post A Comment

Increase Your
Brand Awareness
Auctions + Private Sales
Get The
Best Price
Buy Equipment/Parts
Find The
Lowest Price
Daily News
Read The
Latest News
Browse All
DOTmed Users
Ethics on DOTmed
View Our
Ethics Program
Gold Parts Vendor Program
Receive PH
Gold Service Dealer Program
Receive RFP/PS
Healthcare Providers
See all
HCP Tools
A Job
Parts Hunter +EasyPay
Get Parts
Recently Certified
View Recently
Certified Users
Recently Rated
View Recently
Certified Users
Rental Central
Rent Equipment
For Less
Sell Equipment/Parts
Get The
Most Money
Service Technicians Forum
Find Help
And Advice
Simple RFP
Get Equipment
Virtual Trade Show
Find Service
For Equipment
Access and use of this site is subject to the terms and conditions of our LEGAL NOTICE & PRIVACY NOTICE
Property of and Proprietary to, Inc. Copyright ©2001-2017, Inc.