DOTmed Home MRI Oncology Ultrasound Molecular Imaging X-Ray Cardiology Health IT Business Affairs
News Home Parts & Service Operating Room CT Women's Health Proton Therapy Endoscopy HTMs Mobile Imaging
Current Location:
> This Story

Log in or Register to rate this News Story
Forward Printable StoryPrint Comment



Molecular Imaging Homepage

Physicians halt life-threatening arrhythmias with stereotactic radiation First entirely non-invasive process proposed for treating ventricular tachycardia

PET tracer may help assess promising Alzheimer's treatment Visualizing progress with 18F-AV45 PET imaging agent

New nanoparticle technology may replace MR for cancer detection Shows promise in preclinical study

US Nuclear Corp signs letter of intent to manufacture MIFTEC medical isotope generators Utilizes MIFTI's Staged Z-Pinch fusion technique

The five most important questions to ask about SPECT service Insights from Craig Snodgrass, national service manager at Universal Medical

Cerveau signs research contract with UV Medical Center in Amsterdam For the manufacture and supply of PET agent MK-6240

Expert makes the case for patient access to radiology reports Patients want a more active role in their care

MGH team develops a potential alternative to gadolinium-based contrast agents Made of the vital element manganese

Global PET/CT scanner market projected to reach $2.1 billion by 2023 Growth spurred in part by increased Medicare coverage

Can theranostics be the key to completely curing colorectal cancer? Preclinical trials yield promising results

Transaxial 11C-sarcosine hybrid PET/CT
of the anterior right prostate gland

Courtesy of the University of Michigan

New PET tracer for prostate cancer shows benefits over current standard: study

by Lauren Dubinsky , Senior Reporter
A study recently published in The Journal of Nuclear Medicine may have found a better PET tracer for imaging prostate cancer.

Researchers at the University of Michigan compared the effectiveness of the current standard, 11C-choline, to Carbon-11 labeled sarcosine (11C-sarcosine).

Story Continues Below Advertisement

CT, MRI, NM, SPECT/CT, PET & PET/CT service, refurbished systems and parts

Accelerate your ROI with our Black Diamond Certified refurbished systems. One year warranty - ISO 13485 Certified - FDA registered - Over 65k parts in inventory

Dr. Morand Piert, professor of radiology at the university, explained that 11C-sarcosine was considered for prostate cancer imaging because metabolomic data indicated strongly elevated tissue levels in localized prostate cancer, and particularly in metastatic disease.

Preclinical experiments involving mice revealed that tumor-to-background ratios obtained from 11C-sarcosine PET were much higher than those obtained with 11C-choline. They then performed the first 11C-sarcosine PET/CT scan on a human with prostate cancer and found it can generate high-contrast images.

The researchers concluded that 11C-sarcosine is a viable PET tracer for imaging prostate cancer and has potential benefits over 11C-choline.

Aside from skin cancer, prostate cancer is the most prevalent cancer among men in the U.S. The American Cancer Society estimates that there will be about 161,360 new cases of prostate cancer in 2017.

Sarcosine plays a vital role in the aggressiveness and progression of the disease. It's an excellent imaging target because it enters cells through proton-coupled amino acid transporters (PAT), which are overexpressed in solid tumors.

11C-sarcosine could also be used for identifying and characterizing other types of cancer. According to the researchers, that's because it's the first tracer that can interrogate the activity of PATs.

In the brain, PATs are involved in the neuronal amino acid transport process and in the intestinal tract, certain PATs act as nutrients and drug transporters.

The researchers also noted that PAT function has been connected to the amino acid-sensing engine that drives the activation of an important target for anti-cancer drugs. They believe that elevated 11C-sarcosine may be potentially useful for monitoring cancer treatments, but more research is needed to confirm that.

"The tracer could be useful for malignancies with elevated PAT expression," said Piert. "However, since the PAT expression is unknown for most malignancies, we honestly don't know the answer to the question."

Molecular Imaging Homepage

You Must Be Logged In To Post A Comment

Increase Your
Brand Awareness
Auctions + Private Sales
Get The
Best Price
Buy Equipment/Parts
Find The
Lowest Price
Daily News
Read The
Latest News
Browse All
DOTmed Users
Ethics on DOTmed
View Our
Ethics Program
Gold Parts Vendor Program
Receive PH
Gold Service Dealer Program
Receive RFP/PS
Healthcare Providers
See all
HCP Tools
A Job
Parts Hunter +EasyPay
Get Parts
Recently Certified
View Recently
Certified Users
Recently Rated
View Recently
Certified Users
Rental Central
Rent Equipment
For Less
Sell Equipment/Parts
Get The
Most Money
Service Technicians Forum
Find Help
And Advice
Simple RFP
Get Equipment
Virtual Trade Show
Find Service
For Equipment
Access and use of this site is subject to the terms and conditions of our LEGAL NOTICE & PRIVACY NOTICE
Property of and Proprietary to, Inc. Copyright ©2001-2017, Inc.