Radiation therapy following mastectomy for intermediate-stage, high-risk breast cancer can be shortened from five to three weeks while maintaining tumor control rates in the breast and surrounding region that are equivalent to conventional treatment, according to research presented todayat the 59th Annual Meeting of the American Society for Radiation Oncology (ASTRO).
Five-year results of a Chinese clinical trial with more than 800 post-mastectomy breast cancer patients confirmed that tumor recurrence rates following 15 daily fractions of radiation delivered over three weeks were not inferior to those following 25 fractions. Patients also experienced fewer side effects following accelerated treatment, indicating that hypofractionated radiation following mastectomy is a safe and effective treatment for locally advanced disease.
“Patients with invasive breast cancer receive radiation therapy after tumor-removal surgery to destroy any remaining cancer cells and prevent this very aggressive disease from returning,” said Shulian Wang, MD, one of the study’s lead authors and a radiation oncologist at the Chinese Academy of Medical Sciences in Beijing, China.
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“This trial demonstrates that we can safely accelerate adjuvant radiation therapy and reduce treatment time by two weeks. This option makes treatment more convenient for patients, reduces medical expenses and allows providers to treat more patients with limited resources.”
Of the 820 patients with high-risk breast cancer who enrolled in the trial from 2008 to 2016, 810 were eligible for analysis. The median age was 49 years (range 24-74 years). Nearly all patients (93.9%) had stage III breast cancer, and the remaining 6.1 percent had stage II disease.
All patients underwent mastectomy and received chemotherapy consisting of taxanes and/or anthracycline-based regimens (specifically, 88.6% taxanes and anthracycline, 8.9% taxanes-based, 1.9% anthracycline-based and 0.6% unknown), and some patients received trasuzumab targeted therapy (16.8%) and/or hormonal therapy (76.5% of all patients; 94.5% of those eligible). Patient and disease characteristics did not differ significantly between the treatment groups.
Following mastectomy, patients were randomly assigned in even proportions to receive either accelerated (i.e., hypofractionated) or standard (i.e., conventionally fractionated) external beam radiation therapy to the chest wall and supra-infraclavicular nodal region. The accelerated regimen consisted of 43.5 Gray (Gy) delivered in 15 fractions over three weeks, and the standard regimen consisted of 50 Gy delivered in 25 fractions over five weeks. Treatment was delivered via two-dimensional radiation therapy. Median follow-up for surviving patients was 55 months, with an interquartile range of 36 to 79 months.
