Dublin, Ireland: A new drug designed to make radiotherapy more effective in treating cancer has been given to patients while they are receiving radiation and shown to be safe, according to research presented today (Wednesday) at the 30th EORTC-NCI-AACR [1] Symposium on Molecular Targets and Cancer Therapeutics in Dublin, Ireland.
The drug, called 5-iodo-2-pyrimidinone-2'-deoxribose (IPdR), or ropidoxuridine, has the advantage that patients can take it in capsule form, as opposed to intravenously. When the drug enters the body, researchers believe it changes into an active form that can make cancer cells more susceptible to the effects of radiotherapy.
Results of US NCI trial #9882, presented by Dr Timothy Kinsella from the Department of Radiation Oncology at the Warren Alpert Medical School of Brown University and Rhode Island Hospital in the USA, show that the drug has minimal side effects when given to patients with a variety of gastrointestinal cancers during the course of their radiotherapy.
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Dr Kinsella explained: "The aim of my research is to find better ways to treat patients with cancer, and specifically to develop ways to make radiation treatment safer and more effective.
"Previous research found a promising compound called iododeoxyuridine, or IUdR, that worked very well to improve the effectiveness of radiotherapy, but IUdR could only be given intravenously and proved to have many side effects for patients.
"As a result, this new drug, IPdR, was developed. It's a prodrug that can be taken as a capsule and, once inside the body, it's converted into the active drug, IUdR.
"This trial is the first to test it out in patients while they are receiving radiation therapy, and the results suggest that it's safe with minimal side effects."
Dr Kinsella and his colleagues tested the new drug in a group of 18 patients with advanced cancers including oesophageal, pancreatic, liver, bile duct, rectal and anal cancers. All had been referred for palliative radiotherapy.
Alongside their radiotherapy, patients were given a daily dose of the IPdR prodrug over 28 days. They were given blood tests to check on the levels of both the IPdR prodrug and the active IUdR drug at various points during their treatment. The dose of the prodrug was gradually increased, and patients were monitored for side effects.
Results of the trial suggest that IPdR can be safely given to patients up to a dose of 1200mg per day for 28 days without causing serious side effects. The results also suggest that this dose creates levels of the active IUdR drug in patients' blood that are high enough to have a radiosensitising effect.
