New study shows EarlySign's machine learning algorithm can predict which cardiac patients are at high-risk following discharge

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New study shows EarlySign's machine learning algorithm can predict which cardiac patients are at high-risk following discharge

Press releases may be edited for formatting or style | September 04, 2019 Artificial Intelligence Cardiology
TEL AVIV, Israel and ROCHESTER, Minnesota, Sept. 4, 2019 /PRNewswire/ -- Medial EarlySign (, a leader in machine-learning based solutions to aid in early detection and prevention of high-burden diseases, today announced the results of new research with Mayo Clinic assessing the effectiveness of machine learning for predicting cardiac patients' future risk trajectories following hospital discharge.

The peer-reviewed retrospective data study, Leveraging Machine Learning Techniques to Forecast Patient Prognosis After Percutaneous Coronary Intervention, published in JACC: Cardiovascular Interventions, evaluated the ability of machine learning models to assess risk for patients who underwent percutaneous coronary intervention (PCI) inside the hospital and following their discharge. The analyzed algorithm was developed by Medial EarlySign data scientists to identify patients at highest risk of complications and hospital readmission after undergoing PCI, one of the most frequently performed procedures in U.S. hospitals.

"Contemporary risk models have traditionally had little success in identifying patients' post-PCI risks for complications, in-patient mortality, and hospital readmission. This study shows that machine learning tools may enable cardiology care teams to identify patients who may be on high-risk trajectories," said Rajiv Gulati, MD, Ph.D., Interventional Cardiologist at Mayo Clinic.

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The analysis was based on electronic health records (EHR), demographics, and social data collected from a cohort of 11,709 unique Mayo Clinic patients who underwent 14,349 PCIs during 14,024 hospital admissions. The patients' mean age was 66.9, most were male (71.5%), 45.9% were obese, and 59.8% had a history of heart attacks.

The study revealed that Medial EarlySign's algorithm had an excellent discriminatory ability using only data points available at time of admission or at discharge. Compared with standard regression methods, it was more predictive and discriminative at identifying in-patient sub-groups at high risk for 180-day post-PCI mortality and 30-day rehospitalization for congestive heart failure.

The algorithm also proved effective at identifying patient subgroups at high risk of post-procedure complications and readmission, supporting the potential role for integrating machine learning into clinical practice.

"Machine learning models can help clinicians assess patient risk at different points on their clinical pathways, including hospital admission, discharge and future re-admission," said Yaron Kinar, Ph.D., Medial EarlySign's Chief Data Scientist. "Collaborating with Mayo Clinic clinicians for this retroactive study provided the added benefit of assessing how social and demographic information, together with routine lab and existing EHR data, can provide further insights to stratify patient risk."

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