The mean overall survival for the patients in the study was 397 days; 19 patients died during this time. Based on this follow-up information, researchers determined that the signal-to-background ration (SBR) for an adaptive threshold delineation (PVSBR) method showed a significantly better association with overall survival then the SUVmax or the other two PET segmentation methods.
"The predictive value of the proliferative volume for the overall survival of patients seems to be independent of the postoperative treatment," explained Albert J.S. Idema, MD, lead author of the study. "The importance for patients is the possible utilization of 18-F-FLT PET to select the most appropriate treatment options. The very limited burden that the procedure causes to the patient is a further asset."
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The development of new molecular imaging agents, such as F-18-FLT, which is currently used only for research purposes, has enabled clinical researchers to utilize the agents to assess the characteristics of tumors and their therapeutic response. "We hope that these findings will be helpful for identifying the role of F-18-FLT in assessing the response to antiproliferative treatment in patients with gliomas," said Yamamoto.
Authors of the article "3'-Deoxy-3'-18F-Fluorothymidine PET-Derived Proliferative Volume Predicts Overall Survival in High-Grade Glioma Patients" include Albert J.S. Idema, Hieronymus D. Boogaarts and J. Andre Grotenhuis, Department of Neurosurgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; Aswin L. Hoffmann and Esther G.C. Troost, Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, and Department of Radiation Oncology (MAASTRO), GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands; Pieter Wesseling, Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, and Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands; Arend Heerschap, Department of Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; Winette T.A. van der Graaf, Department of Medical Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; and Wim J.G. Oyen, Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Authors of the article "Correlation of 18F-FLT Uptake with Tumor Grade and Ki-67 Immunohistochemistry in Patients with Newly Diagnosed and Recurrent Gliomas"include Yuka Yamamoto, Yuko Ono, Fumitoshi Aga, and Yoshihiro Nishiyama, Department of Radiology, Faculty of Medicine, Kagawa University, Kagawa, Japan; Nobuyuki Kawai, Department of Neurosurgery, Faculty of Medicine, Kagawa University, Kagawa, Japan; and Nobuyuki Kudomi, Department of Medical Physics, Faculty of Medicine, Kagawa University, Kagawa, Japan.
