"We believe the key to drug delivery in the brain is the precise delivery of the therapeutic agent with immediate visual confirmation of results, to ensure that the full potential of the therapy is measured without apprehension over whether the drug hit its target," said Kim Jenkins, CEO of MRI Interventions. "With ClearPoint and real-time MR imaging, the surgeon can know that the drug hit its target. We look forward to continuing our work with Tocagen and IMRIS at select clinical trial sites to develop and optimize the natural synergy of these technologies."
IMRIS CEO David Graves said that these technologies working together illustrate the benefits of providing imaging at the point of therapy delivery. "This kind of therapy represents the future of neurosurgery and it is enabled by the VISIUS Surgical Theatre platform where exact targeting and delivery of focal therapies can be visualized as they happen."
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In addition to drug delivery, the combination of ClearPoint and VISIUS technologies could offer significant intraoperative advantages in neurosurgical applications including laser ablation therapy, deep brain stimulation surgery, and brain biopsy.
About Toca 511
Tocagen Inc., the clinical trial sponsor, is developing the investigational drug Toca 511 (vocimagene amiretrorepvec) in combination with Toca FC (an investigational extended-release formulation of 5-FC) for the treatment of recurrent high grade glioma, including glioblastoma multiforme (GBM, Grade IV glioma), the most common and aggressive form of brain cancer. Toca 511 is a retroviral replicating vector (RRV) encoding the genetic instructions for the enzyme cytosine deaminase (CD). Toca 511 is designed to selectively infect dividing cancer cells and spread through the tumor after administration. Each patient then begins a course of Toca FC. Within infected cells, the CD enzyme converts 5-FC to the anti-cancer drug 5-FU. By producing 5-FU locally, this technology has the potential to produce much higher concentrations of 5-FU in the tumor than can be safely attained with systemic administration.
Tocagen is presently enrolling patients in its investigational Phase I clinical trials. Currently, University of California, San Francisco; University of California, San Diego; Cleveland Clinic Foundation; and Henry Ford Hospital in Detroit are enrolling patients, and additional sites are in the process of joining this study. For more information about participating in this study, please submit an inquiry form to Tocagen.
