Some of the patients treated with 131I-BA52 were found to have a survival rate of more than two years. Researchers also found that higher treatment doses would have been tolerated in these patients, as only moderate side effects were observed. "We believe that the tracer could be useful in the setting of a combination therapy in patients with metastasized melanoma, especially when applied in earlier stages of the disease where the melanin production is higher as compared to later stages of the disease," noted Uwe Haberkorn, MD, lead author of the study.
Even though new treatments are now available, the prognosis for patients with metastatic melanoma remains very poor. "Innovative strategies are necessary to improve patients' survival. Research focused on innovating targeted-therapy reflects modern oncology, as new theranostic concepts. This strategy nicely illustrates the future of nuclear medicine oncology," said Cachin.
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Authors of the article "123I-BZA2 as a Melanin-Targeted Radiotracerfor the Identification of Melanoma Metastases: Results and Perspectives of a Multicenter Phase III Clinical Trial," include Florent Cachin, Nuclear Medicine, Jean Perrin Cancer Center, Clermont-Ferrand, France, INSERM, UMR 990 IMTV, Clermont Ferrand, France, and Clermont Université, Université d'Auvergne, IMTV, Clermont-Ferrand, France; Elisabeth Miot-Noirault, Jean Michel Chezal and Françoise Degoul, INSERM, UMR 990 IMTV, Clermont Ferrand, France, and Clermont Université, Université d'Auvergne, IMTV, Clermont-Ferrand, France; Brigette Gillet, Dermatology, Estaing University Hospital, Clermont-Ferrand, France; Vanina Isnardi, Nuclear Medicine, University Hospital, Saint-Etienne, France; Bruno Labeille, Dermatology, University Hospital, Saint-Etienne, France; Pierre Payoux, Nuclear Medicine, Purpan University Hospital, Toulouse, France; Nicolas Meyer, Dermatology, Larrey University Hospital, Toulouse, France; Serge Cammilleri, Nuclear Medicine, La Timone University Hospital, Marseille, France; Caroline Gaudy, Dermatology, La Timone University Hospital, Marseille, France; Micheline Razzouk-Cadet, Nuclear Medicine, Archet University Hospital, Nice, France; Jean Phillipe Lacour, Dermatology, Archet University Hospital, Nice, France; Florence Granel-Brocard, Dermatology, Brabois University Hospital, Nancy, France; Christelle Tychyj, Nuclear Medicine, Lyon Sud University Hospital, Hospices Civils de Lyon, Lyon, France; Fathalah Benbouzid and Jean Daniel Grange, Ophthalmology, Croix-Rousse University Hospital, Hospices Civils de Lyon, Lyon, France; Françoise Baulieu, Nuclear Medicine, Trousseau University Hospital, Tours, France; Antony Kelly, Charles Merlin and Daniel Mestas, Nuclear Medicine, Jean Perrin Cancer Center, Clermont-Ferrand, France; Françoise Gachon, Radiopharmacy, Jean Perrin Cancer Center, Clermont-Ferrand, France; and Michel D'Incan, INSERM, UMR 990 IMTV, Clermont Ferrand, France, Clermont Université, Université d'Auvergne, IMTV, Clermont-Ferrand, France, and Dermatology, Estaing University Hospital, Clermont-Ferrand, France.
