Researchers retrospectively analyzed 325 tumor samples from breast cancer patients whose age, survival and cancer pathology (IHC/FISH) findings were known. Median follow-up on those 325 patients was 10.2 years.
The statistically significant results showed that the genomic tests reclassified 25 percent of patients into different subtypes than the subtypes determined by IHC and FISH. By comparing patients' outcomes, researchers determined the overall superiority of the genomic tests over IHC and FISH.
Ad Statistics
Times Displayed: 112999
Times Visited: 6736 MIT labs, experts in Multi-Vendor component level repair of: MRI Coils, RF amplifiers, Gradient Amplifiers Contrast Media Injectors. System repairs, sub-assembly repairs, component level repairs, refurbish/calibrate. info@mitlabsusa.com/+1 (305) 470-8013
MammaPrint and BluePrint more accurately predicted what is known as distant metastasis free survival (DMFS) at 5 years in patients with the various subtypes, including Luminal A-type (best outcome) and triple negative tumors (worse prognosis). BluePrint revealed a different molecular diagnosis than IHC and FISH in all four subtypes of breast cancer:
* 20 out of 208 (10%) diagnosed as luminal-like by IHC/FISH were reclassified as HER2-type (n=7) and as Basal-type (n=13)
* 26 out of 52 (50%) diagnosed as HER2 positive by IHC/FISH were reclassified as Luminal A (n=5), Luminal B (n=13), and Basal-type (n=8)
* 14 out of 65 (22%) diagnosed as triple negative by IHC/FISH were reclassified as Luminal A (n=2), Luminal B (n=5) and Basal-type (n=7)
The American Cancer Society estimates that in the U.S. in 2013, 232,340 women will be diagnosed with and 39,620 women will die of breast cancer.
The SABCS conference is Dec. 10-14. Dr. Cristofanilli's poster ("MammaPrint and BluePrint in early breast cancer: Clinical implications of prognostic stratification and molecular subtyping" P2-11-23) was scheduled to be presented Thursday, Dec. 12 from 7:30-9 a.m CT.
About Jefferson
Thomas Jefferson University (TJU), the largest freestanding academic medical center in Philadelphia, is nationally renowned for medical and health sciences education and innovative research. Founded in 1824, TJU includes Jefferson Medical College (JMC), one of the largest private medical schools in the country and ranked among the nation's best medical schools by U.S. News & World Report, and the Jefferson Schools of Nursing, Pharmacy, Health Professions, Population Health and the Graduate School of Biomedical Sciences. Jefferson University Physicians is TJU's multi-specialty physician practice consisting of the full-time faculty of JMC. Thomas Jefferson University partners with its clinical affiliate, Thomas Jefferson University Hospitals.
Thomas Jefferson University Hospitals (TJUH) is dedicated to excellence in patient care and education. It is consistently ranked by U.S. News & World Report among the nation's top hospitals. It has over 950 licensed acute care beds with major programs in a wide range of clinical specialties. TJUH is one of the few hospitals in the U.S. that is both a Level 1 Trauma Center and a federally-designated regional spinal cord injury center. TJUH patient care facilities include: Jefferson Hospital and Jefferson Hospital for Neuroscience in center city Philadelphia, and Methodist Hospital in South Philadelphia. Additional out-patient sites are located throughout Pennsylvania and New Jersey. TJUH is a part of Jefferson Health System and a partner of Thomas Jefferson University.
